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- W2978256445 abstract "Abstract Background Osimertinib was approved as a standard therapy for EGFR-mutant lung cancer with brain metastasis. It has been demonstrated that TP53 mutations was responsible for Gefitinib resistance in a preclinical study. This study was to analyze the impact of TP53 mutations on response to first-line Osimertinib in EGFR-mutant patients with brain metastasis from non-small cell lung cancer (NSCLC). Methods 100 EGFR-mutated NSCLC patients with brain metastasis receiving first-line Osimertinib were analyzed. TP53 mutations were evaluated in all patients in relation to disease control rate (DCR), progression-free survival (PFS), and overall survival (OS). Results TP53 mutations were observed in 48 (48%), 11 (22.92%), 7 (14.58%), 12 (25%) and 18 (37.5%) patients in exon 5, 6, 7, and 8, respectively. TP53 mutations were significantly associated with increasing brain-metastatic sites (P Conclusions TP53 mutations, especially exon 8 mutations, reduced the efficacy of Osimertinib and worsen prognosis in EGFR-mutated NSCLC patients with brain metastasis. TP53 mutation might be used as a predictor for Osimertinib therapy and a prognostic factor for EGFR-mutated NSCLC patients with brain metastasis. Legal entity responsible for the study Yanqiu Zhao. Funding Has not received any funding. Disclosure All authors have declared no conflicts of interest." @default.
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- W2978256445 date "2019-10-01" @default.
- W2978256445 modified "2023-09-26" @default.
- W2978256445 title "Association between TP53 mutations and efficacy of Osimertinib for brain metastasis from EGFR-mutant lung cancer" @default.
- W2978256445 doi "https://doi.org/10.1093/annonc/mdz243.015" @default.
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