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• W2978315752 abstract "Purpose: Gastroesophageal reflux disease (GERD) is a significant medical problem. Medical GERD treatment often requires expensive chronic proton pump inhibitor therapy, and surgery carries the risks of general anesthesia and post-operative side effects. The goal of this study was to assess the safety and feasibility of endoscopic suturing of the distal esophagus in a porcine model using the Endoscopic Suturing Device (ESD) by Wilson-Cook. Methods: Seven female pigs were fasted for 48 hours prior to having an upper endoscopy on day 0. Using the ESD, two to three sutures were endoscopically placed approximately 5cm proximal to the GE junction in each animal. The animals were then recovered, and their activity and behavior was monitored for six days post-procedure with weights on day+2, day+4, and day+6. The animals were sacrificed on day+6, and the suture sites were inspected for any gross evidence of inflammation, abscess, or hemorrhage. Results: There were no significant complications, and none of the animals had any obvious difficulty eating post-procedure. Two animals had transient lethargy. There was no statistically significant difference between the mean weights of the animals in kg on day+2 (48.0), day+4 (48.7), and day+6 (48.3) compared to baseline on day 0 (47.9) with P-values of 0.93, 0.48, and 0.61, respectively. Inspection of the suture sites at the time of sacrifice revealed that 9 of 16 sutures (56%) remained in place and did not reveal any gross evidence of inflammation, abscess, or hemorrhage. Conclusions: Endoscopic suturing of the distal esophagus using the ESD from Wilson-Cook seems to be safe and feasible. More experience with the device will likely result in higher rates of suture retention. Further animal studies employing both pH probe technology and histologic evaluation of the suture sites would be helpful to investigate the physiologic benefits of the procedure." @default.
• W2978315752 created "2019-10-10" @default.
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• W2978315752 date "2004-10-01" @default.
• W2978315752 modified "2023-09-25" @default.
• W2978315752 title "ENDOSCOPIC SUTURING OF THE DISTAL ESOPHAGUS IN A PORCINE MODEL" @default.
• W2978315752 doi "https://doi.org/10.14309/00000434-200410001-00911" @default.
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