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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978340034> ?p ?o ?g. }

• W2978340034 endingPage "6868" @default.
• W2978340034 startingPage "6854" @default.
• W2978340034 abstract "The Rift Valley fever virus (RVFV) is an emerging high-priority pathogen endemic in Africa with pandemic potential. There is no specific treatment or approved antiviral drugs for the RVFV. We previously developed a cell-based high-throughput assay to screen small molecules targeting the RVFV and identified a potential effective antiviral compound (1-N-(2-(biphenyl-4-yloxy)ethyl)propane-1,3-diamine) as a lead compound. Here, we investigated how structural modifications of the lead compound affected the biological properties and the antiviral effect against the RVFV. We found that the length of the 2-(3-aminopropylamino)ethyl chain of the compound was important for the compound to retain its antiviral activity. The antiviral activity was similar when the 2-(3-aminopropylamino)ethyl chain was replaced with a butyl piperazine chain. However, we could improve the cytotoxicity profile of the lead compound by changing the phenyl piperazine linker from the para-position (compound 9a) to the meta-position (compound 13a). Results from time-of-addition studies suggested that compound 13a might be active during virus post-entry and/or the replication phase of the virus life cycle and seemed to affect the K+ channel. The modifications improved the properties of our lead compound, and our data suggest that 13a is a promising candidate to evaluate further as a therapeutic agent for RVFV infection." @default.
• W2978340034 created "2019-10-10" @default.
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• W2978340034 date "2022-02-16" @default.
• W2978340034 modified "2023-10-14" @default.
• W2978340034 title "Structural Modifications and Biological Evaluations of Rift Valley Fever Virus Inhibitors Identified from Chemical Library Screening" @default.
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• W2978340034 doi "https://doi.org/10.1021/acsomega.1c06513" @default.
• W2978340034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35252679" @default.
• W2978340034 hasPublicationYear "2022" @default.
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