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- W2978341177 abstract "Introduction: Alcohol use disorder was estimated to affect 16.3 million adults, and accounted for $249.0 billion in healthcare costs and is known to be the 4th leading cause of preventable death in United States. Alcohol consumption is associated with development of liver disease, pancreatitis, and alcohol induced mental disorders. However, little is known of the differences in rates of prevalence and hospitalization, and whether there is an overlap between these disorders in chronic alcoholics. Our hypothesis is that alcohol related end-organ damage is dependent on individual susceptibility of different pathways to alcohol exposure. The aim of this study was to evaluate the rates of alcohol related pancreatitis, liver diseases and neuropsychatric disorders. Methods: The National Inpatient Sample (NIS) database for year 2011 was queried for ICD-9 discharge diagnosis of alcoholic liver disease (ALD), alcoholic acute- or chronic -pancreatitis (ALP), and alcohol related mental disorders (ALMS) including withdrawal, psychosis and delirium. Patients were grouped into seven groups ALD only, ALP only, ALMS only, ALD+ALP, ALD+ALM, ALP+ALM, and ALD+ALP+ALM. Demographic characters, length of stay, hospitalization charges and death were noted for all the groups. Venn diagram was used to demonstrate the degree of overlap between the study groups. Univariable analysis was performed using logistic regression among the groups, and a p value of < 0.01 was considered significant. Results: A total of 158, 407 admissions were retrieved, with a mean age of 51 ± 12.6 years, 72.8% males, and 68% white. Figure 1 demonstrates the Venn diagram between the study groups which shows minimal overlap between the 3 groups of < 16% in the entire cohort. Table 1 demonstrates the demographic and clinical outcome in various study groups. Patients with ALD only were significantly older than other groups, and were associated with higher hospitalization charges and increased LOS. Patients with ALD only had a higher rate of mortality at 7% compared to an average of 3% in other groups.Figure 1Table 1: Demographic and Clinical Outcome in Alcoholic Related- Pancreatitis, Alcohol Liver Disease and Mental DisordersConclusion: There is a significant difference in the rates and mortality of alcoholic pancreatitis, alcoholic liver disease, and alcohol related mental disorders. There is little overlap between the prevalence of these three disorders, and further studies are needed to investigate the different pathways of end-organ damage in alcoholic consumption." @default.
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- W2978341177 date "2016-10-01" @default.
- W2978341177 modified "2023-09-27" @default.
- W2978341177 title "Epidemiological Trends of End-organ Damage with Alcohol Consumption: Liver, Pancreas and Neuropsychiatric Disorders" @default.
- W2978341177 doi "https://doi.org/10.14309/00000434-201610001-00971" @default.
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