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- W2978355982 abstract "Purpose: Primary squamous cell carcinoma (SCC) of the GI tract is a rare malignancy with a far lower incidence than primary adenosquamous cell carcinoma of the GI tract. Schmidtmann described the first case in 1919 by presenting a squamous cell carcinoma of the large intestine localized to the cecum. Of the locations described in literature, primary rectal SCC tumors were the most frequent, followed by the right colon. Primary squamous cell carcinoma of the rectum has an incidence 0.1 per 1000 colorectal carcinomas, with fewer than one hundred cases described in literature since 1919. The patient is a 50-year-old male with PMH significant for HIV off HAART and no history of AIDS defining illness, who presented to the ED with complaint left-sided pain, mid abdominal tenderness, and constipation with significant straining to use the bathroom and dark/bloody stools. He reported he had an external rectal condyloma removed four months prior to admission. The patient noted 10 pounds weight loss over last four months. The patient noticed significant constipation, thin stools and in the last month dark blood with bowel movements (never occurred prior), and has had increasing abdominal pain initially mid epigastric, 5/10 aching, but then progressed to right upper abdomen and then diffuse. He had his first occurrence of bright red blood with bowel movement, which prompted admission. The patient's vitals were stable, and on exam, his abdomen was significant for distention, tenderness to mid-epigastric region, hepatomegaly, external hemorrhoids, and guaiac-positive stool. Other systems were normal. Laboratory results were significant for hemoglobin of 7.3 g/dl, albumin of 2.8 g/dl, and corrected calcium of 13.8 mg/dl. Computed tomography (CT) revealed perirectal mass, diffuse lymphadenopathy, and multiple hepatic masses. Colonoscopy with approximately 4 cm non-obstructing firm and friable mass located at the junction of the anal canal and rectum. Rectal mass pathology consistent with invasive, poorly-differentiated squamous cell carcinoma with basaloid features. Due to advanced stages and aggressive nature of his cancer, the patient was started on palliative radiation with 45 Gy in 15 fractions to the anus and 30 Gy in 15 fractions to the liver. Prognosis has been reported very poor in this case.Figure" @default.
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- W2978355982 date "2013-10-01" @default.
- W2978355982 modified "2023-10-14" @default.
- W2978355982 title "Squamous Cell Carcinoma of the Rectum: A Case Report of a Rare Disorder" @default.
- W2978355982 doi "https://doi.org/10.14309/00000434-201310001-01375" @default.
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