Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978366977> ?p ?o ?g. }
- W2978366977 endingPage "712.e6" @default.
- W2978366977 startingPage "697" @default.
- W2978366977 abstract "To investigate the contribution of parental genomes to early embryogenesis, we profiled the single-cell transcriptomes of human biparental and uniparental embryos systematically from the 1-cell to the morula stage. We observed that uniparental embryos exhibited variable and decreased embryonic genome activation (EGA). Comparative transcriptome analysis identified 807 maternally biased expressed genes (MBGs) and 581 paternally biased expressed genes (PBGs) in the preimplantation stages. MBGs became apparent at the 4-cell stage and contributed to the initiation of EGA, whereas PBGs preferentially appeared at the 8-cell stage and might affect embryo compaction and trophectoderm specification. Regulatory network analysis revealed that DUX4, EGR2, and DUXA are key transcription factors in MBGs’ expression; ZNF263 and KLF3 are important for PBGs’ expression. We demonstrated that parent-specific DNA methylation might account for the expression of most PBGs. Our results provide a valuable resource to understand parental genome activation and might help to elucidate parent-of-origin effects in early human development." @default.
- W2978366977 created "2019-10-10" @default.
- W2978366977 creator A5000026105 @default.
- W2978366977 creator A5003385574 @default.
- W2978366977 creator A5006334228 @default.
- W2978366977 creator A5008818288 @default.
- W2978366977 creator A5010587223 @default.
- W2978366977 creator A5017431309 @default.
- W2978366977 creator A5030424192 @default.
- W2978366977 creator A5036195699 @default.
- W2978366977 creator A5039270495 @default.
- W2978366977 creator A5043490198 @default.
- W2978366977 creator A5045389088 @default.
- W2978366977 creator A5046382012 @default.
- W2978366977 creator A5060074260 @default.
- W2978366977 creator A5062116814 @default.
- W2978366977 creator A5080552339 @default.
- W2978366977 creator A5084138424 @default.
- W2978366977 date "2019-11-01" @default.
- W2978366977 modified "2023-10-16" @default.
- W2978366977 title "Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development" @default.
- W2978366977 cites W1964164411 @default.
- W2978366977 cites W1967327758 @default.
- W2978366977 cites W1973073700 @default.
- W2978366977 cites W1978386737 @default.
- W2978366977 cites W1980213937 @default.
- W2978366977 cites W1981197560 @default.
- W2978366977 cites W1986504960 @default.
- W2978366977 cites W1987557775 @default.
- W2978366977 cites W2005942028 @default.
- W2978366977 cites W2007439698 @default.
- W2978366977 cites W2014386129 @default.
- W2978366977 cites W2014677321 @default.
- W2978366977 cites W2015404151 @default.
- W2978366977 cites W2023887100 @default.
- W2978366977 cites W2028441878 @default.
- W2978366977 cites W2038254017 @default.
- W2978366977 cites W2041760692 @default.
- W2978366977 cites W2046031617 @default.
- W2978366977 cites W2056069396 @default.
- W2978366977 cites W2057061886 @default.
- W2978366977 cites W2063965401 @default.
- W2978366977 cites W2065340354 @default.
- W2978366977 cites W2068767807 @default.
- W2978366977 cites W2074027720 @default.
- W2978366977 cites W2076172271 @default.
- W2978366977 cites W2080018890 @default.
- W2978366977 cites W2082290099 @default.
- W2978366977 cites W2084942072 @default.
- W2978366977 cites W2086277161 @default.
- W2978366977 cites W2100522482 @default.
- W2978366977 cites W2102021831 @default.
- W2978366977 cites W2103441770 @default.
- W2978366977 cites W2103469935 @default.
- W2978366977 cites W2106557257 @default.
- W2978366977 cites W2106889224 @default.
- W2978366977 cites W2107202213 @default.
- W2978366977 cites W2114517226 @default.
- W2978366977 cites W2116734905 @default.
- W2978366977 cites W2118209929 @default.
- W2978366977 cites W2121417064 @default.
- W2978366977 cites W2121690903 @default.
- W2978366977 cites W2129530584 @default.
- W2978366977 cites W2131271579 @default.
- W2978366977 cites W2134526812 @default.
- W2978366977 cites W2135942473 @default.
- W2978366977 cites W2140952049 @default.
- W2978366977 cites W2142705894 @default.
- W2978366977 cites W2146767125 @default.
- W2978366977 cites W2156295197 @default.
- W2978366977 cites W2156910122 @default.
- W2978366977 cites W2169456326 @default.
- W2978366977 cites W2171762081 @default.
- W2978366977 cites W2273663185 @default.
- W2978366977 cites W2287766201 @default.
- W2978366977 cites W2307567449 @default.
- W2978366977 cites W2326766364 @default.
- W2978366977 cites W2343956310 @default.
- W2978366977 cites W2409806253 @default.
- W2978366977 cites W2515884013 @default.
- W2978366977 cites W2518658526 @default.
- W2978366977 cites W2558947257 @default.
- W2978366977 cites W2591733518 @default.
- W2978366977 cites W2592811885 @default.
- W2978366977 cites W2611165465 @default.
- W2978366977 cites W2611346822 @default.
- W2978366977 cites W2611929604 @default.
- W2978366977 cites W2736763193 @default.
- W2978366977 cites W2749706640 @default.
- W2978366977 cites W2772960489 @default.
- W2978366977 cites W2773931390 @default.
- W2978366977 cites W2790732445 @default.
- W2978366977 cites W2947358735 @default.
- W2978366977 cites W2951890476 @default.
- W2978366977 cites W2952303649 @default.
- W2978366977 doi "https://doi.org/10.1016/j.stem.2019.09.004" @default.
- W2978366977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31588047" @default.
- W2978366977 hasPublicationYear "2019" @default.