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• W2978397311 abstract "Purpose: The wireless pH monitoring system (Bravo Capsule) is better tolerated and allows longer period of recording (48 hours) in patients evaluated for gastroesophageal reflux disease. The problem is that significant day to day discrepancy in measurement of acid exposure occurs. This variation is thought to be due to the sedation used during the endoscopic placement of the capsule. An alternative is placing the capsule transnasally based on motility measurements of the Lower Esophageal Sphincter (LES). We decided to assess if such a policy affects day to day discrepancy and if so, did the variability depend on the status of the gastroesophageal barrier. Methods: Study population consisted of 310 patients who had Bravo capsule placed transnasally based on manometric measurements of the LES. Based on composite score patients were divided in 3 groups: both days abnormal, both days normal and those with score discrepancy between first and second day. LES characteristic were compared in these groups. In addition, in the group with discrepancy the response of LES to a test meal was studied by calculating a post/pre prandial acid exposure ratio. Results: Of the 310 patients evaluated 60 (19%) had a discrepancy in score between the two days, 127 had a normal score and 123 an abnormal score on both days. Of the 60 patients with discrepancy, 27 were abnormal the first day and 33 were abnormal the second day. Patients with abnormal esophageal acid exposure on both days tend to have more defective LES compared to those with abnormal score only in one day. (33.3%, 51.2%, P= 0.027). Sphincter characteristic comparison for all 3 groups is shown (Table). In the 28 patients with discrepancy a test meal was given. Ten patients (36%) had an abnormal post/pre prandial acid exposure ratio on the normal day.TableConclusion: Manometric placement of Bravo capsule results in less discrepant pH recording between first and second 24 hours compared to previously reported placement via endoscopy. Patients with abnormal pH on both days tend to have a greater prevalence of defective valve than those with abnormal score on one day. This variability between the 2 days may represent impairment of gastroesophageal barrier in patients with early reflux disease." @default.
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• W2978397311 date "2008-09-01" @default.
• W2978397311 modified "2023-09-23" @default.
• W2978397311 title "Manometric Placement of BRAVO Capsule and Its Impact on Day to Day Discrepancy in Measurement of Esophageal Acid Exposure" @default.
• W2978397311 doi "https://doi.org/10.14309/00000434-200809001-00023" @default.
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