Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978404406> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2978404406 endingPage "940" @default.
- W2978404406 startingPage "933" @default.
- W2978404406 abstract "The assessment of drug-drug interaction (DDI) is important not only for safety but also for maintaining the efficacy of direct acting antivirals in chronic hepatitis C (CHC). This study aims to evaluate DDI before and during elbasvir/grazoprevir (EBR/GZR) treatment.CHC patients who treated with EBR/GZR in five hospitals were enrolled. The patients' demographic data, comorbidities, concomitant medications taken before and during EBR/GZR were recorded. DDI was evaluated using a tool from the HEP Drug Interactions (www.hep-druginteractions.org) website. In addition to the evaluation of DDI for EBR/GZR, the virtual DDI of ledipasvir/sofosbuvir (LDV/SOF), sofosbuvir/velpatasvir (SOF/VEL) and glecaprevir/pibrentasvir (GLE/PIB) were evaluated. Degrees of DDI were classified as do not co-administer, potential interaction, and potentially weak interaction.A total of 460 patients were enrolled. At baseline, 80.1% of patients had one or more comorbidities and 72.8% took one or more medications. Cardiovascular diseases (43.9%), gastrointestinal diseases (37.4%), and metabolic diseases (36.7%) were the three most common comorbidities. The prevalence of DDI before EBR/GZR treatment was 12.8% (59 patients). Among the same population, the prevalence of virtual DDI of SOF/VEL, GLE/PIB, and LDV/SOF were 38.5% (179 patients), 48.8% (220 patients), and 57.0% (262 patients), respectively. During EBR/GZR treatment, 167 patients (36.3%) took newly prescribed medications. One patient (0.2%) and seven patients (1/5%) exhibited do-not-co-administer and potential interaction with EBR/GZR, respectively.DDI was limited in treatment with EBR/GZR. DDI can occur upon the administering of a new medication during antiviral treatment and attention should be paid to it.NCT03706222." @default.
- W2978404406 created "2019-10-10" @default.
- W2978404406 creator A5014616963 @default.
- W2978404406 creator A5048460639 @default.
- W2978404406 creator A5057043300 @default.
- W2978404406 creator A5072593323 @default.
- W2978404406 creator A5090245512 @default.
- W2978404406 date "2020-05-01" @default.
- W2978404406 modified "2023-10-18" @default.
- W2978404406 title "Limited drug–drug interaction of elbasvir/grazoprevir for chronic hepatitis C" @default.
- W2978404406 cites W1989093608 @default.
- W2978404406 cites W2011337332 @default.
- W2978404406 cites W2042063943 @default.
- W2978404406 cites W2080081537 @default.
- W2978404406 cites W2170706646 @default.
- W2978404406 cites W2185218296 @default.
- W2978404406 cites W2241552982 @default.
- W2978404406 cites W2316541736 @default.
- W2978404406 cites W2514340439 @default.
- W2978404406 cites W2519434695 @default.
- W2978404406 cites W2592128079 @default.
- W2978404406 cites W2592428844 @default.
- W2978404406 cites W2735669709 @default.
- W2978404406 cites W2767217085 @default.
- W2978404406 cites W2783368644 @default.
- W2978404406 cites W2806380084 @default.
- W2978404406 cites W2898505054 @default.
- W2978404406 cites W2909099710 @default.
- W2978404406 doi "https://doi.org/10.1016/j.jfma.2019.09.011" @default.
- W2978404406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31594667" @default.
- W2978404406 hasPublicationYear "2020" @default.
- W2978404406 type Work @default.
- W2978404406 sameAs 2978404406 @default.
- W2978404406 citedByCount "4" @default.
- W2978404406 countsByYear W29784044062020 @default.
- W2978404406 countsByYear W29784044062021 @default.
- W2978404406 countsByYear W29784044062023 @default.
- W2978404406 crossrefType "journal-article" @default.
- W2978404406 hasAuthorship W2978404406A5014616963 @default.
- W2978404406 hasAuthorship W2978404406A5048460639 @default.
- W2978404406 hasAuthorship W2978404406A5057043300 @default.
- W2978404406 hasAuthorship W2978404406A5072593323 @default.
- W2978404406 hasAuthorship W2978404406A5090245512 @default.
- W2978404406 hasBestOaLocation W29784044061 @default.
- W2978404406 hasConcept C126322002 @default.
- W2978404406 hasConcept C159047783 @default.
- W2978404406 hasConcept C2522874641 @default.
- W2978404406 hasConcept C2775999097 @default.
- W2978404406 hasConcept C2778390639 @default.
- W2978404406 hasConcept C2779384505 @default.
- W2978404406 hasConcept C2780035454 @default.
- W2978404406 hasConcept C2780040827 @default.
- W2978404406 hasConcept C2908647359 @default.
- W2978404406 hasConcept C3020491458 @default.
- W2978404406 hasConcept C71924100 @default.
- W2978404406 hasConcept C98274493 @default.
- W2978404406 hasConcept C99454951 @default.
- W2978404406 hasConceptScore W2978404406C126322002 @default.
- W2978404406 hasConceptScore W2978404406C159047783 @default.
- W2978404406 hasConceptScore W2978404406C2522874641 @default.
- W2978404406 hasConceptScore W2978404406C2775999097 @default.
- W2978404406 hasConceptScore W2978404406C2778390639 @default.
- W2978404406 hasConceptScore W2978404406C2779384505 @default.
- W2978404406 hasConceptScore W2978404406C2780035454 @default.
- W2978404406 hasConceptScore W2978404406C2780040827 @default.
- W2978404406 hasConceptScore W2978404406C2908647359 @default.
- W2978404406 hasConceptScore W2978404406C3020491458 @default.
- W2978404406 hasConceptScore W2978404406C71924100 @default.
- W2978404406 hasConceptScore W2978404406C98274493 @default.
- W2978404406 hasConceptScore W2978404406C99454951 @default.
- W2978404406 hasFunder F4320332932 @default.
- W2978404406 hasIssue "5" @default.
- W2978404406 hasLocation W29784044061 @default.
- W2978404406 hasLocation W29784044062 @default.
- W2978404406 hasOpenAccess W2978404406 @default.
- W2978404406 hasPrimaryLocation W29784044061 @default.
- W2978404406 hasRelatedWork W2418485874 @default.
- W2978404406 hasRelatedWork W2522881653 @default.
- W2978404406 hasRelatedWork W2526504476 @default.
- W2978404406 hasRelatedWork W2579037114 @default.
- W2978404406 hasRelatedWork W2613629952 @default.
- W2978404406 hasRelatedWork W2762908165 @default.
- W2978404406 hasRelatedWork W2898505054 @default.
- W2978404406 hasRelatedWork W2909634947 @default.
- W2978404406 hasRelatedWork W3008813722 @default.
- W2978404406 hasRelatedWork W3108732961 @default.
- W2978404406 hasVolume "119" @default.
- W2978404406 isParatext "false" @default.
- W2978404406 isRetracted "false" @default.
- W2978404406 magId "2978404406" @default.
- W2978404406 workType "article" @default.