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• W2978438963 abstract "Purpose: VA Cooperative Study 380 determined that approximately 30% of men with advanced colonic neoplasia (i.e., adenoma >10 mm, villous adenoma, adenoma with high-grade dysplasia or colorectal cancer) would have their lesions missed if only flexible sigmoidoscopy were performed. The CONCe RN Study is a tandem study of VA Cooperative Study 380 and defines the yield of flexible sigmoidoscopy and screening colonoscopy in women. Methods: Consecutive asymptomatic women referred for screening were offered colonoscopy to determine the prevalence and location of advanced colonic neoplasia and the yield of flexible sigmoidoscopy (i.e., proportion of patients with advanced colonic neoplasia who had this advanced lesion in the distal colon or who had advanced colonic neoplasia in the proximal colon with synchronous small adenomas in the distal colon). Female patients in this study were then matched by age, (—) fecal occult blood status, and (—) family history of colon cancer with male patients in VA Cooperative Study 380. Results: 1483 women enrolled, and colonoscopy was complete in 1463 women (98.7%). Colonoscopy revealed advanced neoplasia in 4.9% (72/1463) and colonoscopy revealed one or more adenomas in 20.4% (299/1463). If only flexible sigmoidoscopy was performed, then 1.7% (25/1463) of women would have advanced colonic neoplasia identified, and 3.2% (47/1463) of women would have advanced colonic neoplasia missed. Thus, the yield of flexible sigmoidoscopy was only 35% in women The yield of flexible sigmoidoscopy for identifying advanced colonic neoplasia was lower in women versus for matched men from VA Cooperative 380 (35% vs 66%, p <0.01). However, men were more likely to have advanced neoplasia than women in 50–59 years old group: 4.7% (35/743) vs. 2.9% (20/689); [RR = 1.62 (95% CI: 0.95-2.78)] and in 60–69 years old group: 10.6% (112/1057) vs. 5.0% (19/382); [RR =2.13 (95% CI: 1.33-3.42)], but in the 70–79 years old group, men were not more likely to have advanced neoplasia than women: 10.6% (43/406) vs. 11.8% (15/127). Conclusions: Colonoscopy may be the preferred colorectal cancer screening tool for women." @default.
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• W2978438963 date "2004-10-01" @default.
• W2978438963 modified "2023-10-14" @default.
• W2978438963 title "COLONOSCOPY IS THE PREFERRED COLORECTAL CANCER SCREENING TOOL IN WOMEN" @default.
• W2978438963 doi "https://doi.org/10.14309/00000434-200410001-00343" @default.
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