FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978440466> ?p ?o ?g. }

• W2978440466 endingPage "13643" @default.
• W2978440466 startingPage "13632" @default.
• W2978440466 abstract "Mucosal wound repair is coordinated by dynamic crosstalk between endogenous and exogenous mediators and specific receptors on epithelial cells and infiltrating immune cells. One class of such receptor‐ligand pairs involves formyl peptide receptors (FPRs) that have been shown to influence inflammatory response and repair. Here we explored the role of murine Fpr2/3, an ortholog of human FPR2/receptor for lipoxin A4 (ALX), in orchestrating intestinal mucosal repair. Compared with wild‐type (WT) mice, Fpr2/3 –/– mice exhibited delayed recovery from acute experimental colitis and perturbed repair after biopsy‐induced colonic mucosal injury. Decreased numbers of infiltrating monocytes were observed in healing wounds from Fpr2/3 –/– mice compared with WT animals. Bone marrow transplant experiments revealed that Fpr2/3 –/– monocytes showed a competitive disadvantage when infiltrating colonic wounds. Moreover, Fpr2/3 –/– monocytes were defective in chemotactic responses to the chemokine CC chemokine ligand (CCL)20, which is up‐regulated during early phases of inflammation. Analysis of Fpr2/3 –/– monocytes revealed altered expression of the CCL20 receptor CC chemokine receptor (CCR)6, suggesting that Fpr2/3 regulates CCL20‐CCR6‐mediated monocyte chemotaxis to sites of mucosal injury in the gut. These findings demonstrate an important contribution of Fpr2/3 in facilitating monocyte recruitment to sites of mucosal injury to influence wound repair.—Birkl, D., O'Leary, M. N., Quiros, M., Azcutia, V., Schaller, M., Reed, M., Nishio, H., Keeney, J., Neish, A. S., Lukacs, N. W., Parkos, C. A., Nusrat, A. Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair. FASEB J. 33, 13632‐13643 (2019). www.fasebj.org" @default.
• W2978440466 created "2019-10-10" @default.
• W2978440466 creator A5003674452 @default.
• W2978440466 creator A5010824578 @default.
• W2978440466 creator A5014144418 @default.
• W2978440466 creator A5045329624 @default.
• W2978440466 creator A5047243105 @default.
• W2978440466 creator A5061165510 @default.
• W2978440466 creator A5071980322 @default.
• W2978440466 creator A5074708797 @default.
• W2978440466 creator A5078257803 @default.
• W2978440466 creator A5088545837 @default.
• W2978440466 creator A5088974704 @default.
• W2978440466 creator A5090537017 @default.
• W2978440466 date "2019-10-04" @default.
• W2978440466 modified "2023-10-15" @default.
• W2978440466 title "Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair" @default.
• W2978440466 cites W1592678705 @default.
• W2978440466 cites W1835961422 @default.
• W2978440466 cites W1886627155 @default.
• W2978440466 cites W1955937578 @default.
• W2978440466 cites W1968890426 @default.
• W2978440466 cites W1978186126 @default.
• W2978440466 cites W1978740584 @default.
• W2978440466 cites W1979751791 @default.
• W2978440466 cites W1982159359 @default.
• W2978440466 cites W1990014836 @default.
• W2978440466 cites W1990666750 @default.
• W2978440466 cites W1996079126 @default.
• W2978440466 cites W1997048360 @default.
• W2978440466 cites W1998470464 @default.
• W2978440466 cites W2000987582 @default.
• W2978440466 cites W2001286841 @default.
• W2978440466 cites W2004536682 @default.
• W2978440466 cites W2023128342 @default.
• W2978440466 cites W2023668858 @default.
• W2978440466 cites W2028653503 @default.
• W2978440466 cites W2032527022 @default.
• W2978440466 cites W2044701263 @default.
• W2978440466 cites W2045549203 @default.
• W2978440466 cites W2054895562 @default.
• W2978440466 cites W2056879548 @default.
• W2978440466 cites W2059413226 @default.
• W2978440466 cites W2073860070 @default.
• W2978440466 cites W2079168625 @default.
• W2978440466 cites W2082160731 @default.
• W2978440466 cites W2085430804 @default.
• W2978440466 cites W2089411255 @default.
• W2978440466 cites W2091598017 @default.
• W2978440466 cites W2096116412 @default.
• W2978440466 cites W2103468046 @default.
• W2978440466 cites W2103555767 @default.
• W2978440466 cites W2104449005 @default.
• W2978440466 cites W2110722277 @default.
• W2978440466 cites W2128829928 @default.
• W2978440466 cites W2131896212 @default.
• W2978440466 cites W2134326405 @default.
• W2978440466 cites W2140552250 @default.
• W2978440466 cites W2141710693 @default.
• W2978440466 cites W2143448489 @default.
• W2978440466 cites W2146314181 @default.
• W2978440466 cites W2148123030 @default.
• W2978440466 cites W2152157516 @default.
• W2978440466 cites W2154806546 @default.
• W2978440466 cites W2155081125 @default.
• W2978440466 cites W2159543436 @default.
• W2978440466 cites W2159913536 @default.
• W2978440466 cites W2167080613 @default.
• W2978440466 cites W2167503339 @default.
• W2978440466 cites W2186067674 @default.
• W2978440466 cites W2301044272 @default.
• W2978440466 cites W2333427125 @default.
• W2978440466 cites W2486949243 @default.
• W2978440466 cites W2595655718 @default.
• W2978440466 cites W2726488683 @default.
• W2978440466 cites W2737866312 @default.
• W2978440466 cites W2743633448 @default.
• W2978440466 cites W2762717141 @default.
• W2978440466 cites W2789381621 @default.
• W2978440466 cites W2797069917 @default.
• W2978440466 cites W2939456931 @default.
• W2978440466 cites W4231085290 @default.
• W2978440466 cites W4239009929 @default.
• W2978440466 doi "https://doi.org/10.1096/fj.201901163r" @default.
• W2978440466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6894067" @default.
• W2978440466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31585047" @default.
• W2978440466 hasPublicationYear "2019" @default.
• W2978440466 type Work @default.
• W2978440466 sameAs 2978440466 @default.
• W2978440466 citedByCount "30" @default.
• W2978440466 countsByYear W29784404662020 @default.
• W2978440466 countsByYear W29784404662021 @default.
• W2978440466 countsByYear W29784404662022 @default.
• W2978440466 countsByYear W29784404662023 @default.
• W2978440466 crossrefType "journal-article" @default.
• W2978440466 hasAuthorship W2978440466A5003674452 @default.
• W2978440466 hasAuthorship W2978440466A5010824578 @default.
• W2978440466 hasAuthorship W2978440466A5014144418 @default.

• next