FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978482811> ?p ?o ?g. }

• W2978482811 endingPage "3609" @default.
• W2978482811 startingPage "3609" @default.
• W2978482811 abstract "Background: Boron Neutron Capture Therapy (BNCT) is a binary approach to cancer therapy that requires accumulation of boron atoms preferentially in tumour cells. This can be achieved by using nanoparticles as boron carriers and taking advantage of the enhanced permeability and retention (EPR) effect. Here, we present the preparation and characterization of size and shape-tuned gold NPs (AuNPs) stabilised with polyethylene glycol (PEG) and functionalized with the boron-rich anion cobalt bis(dicarbollide), commonly known as COSAN. The resulting NPs were radiolabelled with 124I both at the core and the shell, and were evaluated in vivo in a mouse model of human fibrosarcoma (HT1080 cells) using positron emission tomography (PET). Methods: The thiolated COSAN derivatives for subsequent attachment to the gold surface were synthesized by reaction of COSAN with tetrahydropyran (THP) followed by ring opening using potassium thioacetate (KSAc). Iodination on one of the boron atoms of the cluster was also carried out to enable subsequent radiolabelling of the boron cage. AuNPs grafted with mPEG-SH (5 Kda) and thiolated COSAN were prepared by ligand displacement. Radiolabelling was carried out both at the shell (isotopic exchange) and at the core (anionic absorption) of the NPs using 124I to enable PET imaging. Results: Stable gold nanoparticles simultaneously functionalised with PEG and COSAN (PEG-AuNPs@[4]-) with hydrodynamic diameter of 37.8 ± 0.5 nm, core diameter of 19.2 ± 1.4 nm and ξ-potential of -18.0 ± 0.7 mV were obtained. The presence of the COSAN on the surface of the NPs was confirmed by Raman Spectroscopy and UV-Vis spectrophotometry. PEG-AuNPs@[4]- could be efficiently labelled with 124I both at the core and the shell. Biodistribution studies in a xenograft mouse model of human fibrosarcoma showed major accumulation in liver, lungs and spleen, and poor accumulation in the tumour. The dual labelling approach confirmed the in vivo stability of the PEG-AuNPs@[4]-. Conclusions: PEG stabilized, COSAN-functionalised AuNPs could be synthesized, radiolabelled and evaluated in vivo using PET. The low tumour accumulation in the animal model assayed points to the need of tuning the size and geometry of the gold core for future studies." @default.
• W2978482811 created "2019-10-10" @default.
• W2978482811 creator A5015299923 @default.
• W2978482811 creator A5024706803 @default.
• W2978482811 creator A5031903323 @default.
• W2978482811 creator A5037405149 @default.
• W2978482811 creator A5046763218 @default.
• W2978482811 creator A5062821752 @default.
• W2978482811 creator A5074629222 @default.
• W2978482811 creator A5080024707 @default.
• W2978482811 creator A5080073728 @default.
• W2978482811 date "2019-10-07" @default.
• W2978482811 modified "2023-10-15" @default.
• W2978482811 title "Gold Nanoparticles as Boron Carriers for Boron Neutron Capture Therapy: Synthesis, Radiolabelling and In vivo Evaluation" @default.
• W2978482811 cites W1023786367 @default.
• W2978482811 cites W1964358584 @default.
• W2978482811 cites W1965361239 @default.
• W2978482811 cites W1966916682 @default.
• W2978482811 cites W1970020123 @default.
• W2978482811 cites W1971372131 @default.
• W2978482811 cites W1977721654 @default.
• W2978482811 cites W1984539239 @default.
• W2978482811 cites W1989341491 @default.
• W2978482811 cites W1991142673 @default.
• W2978482811 cites W1991917341 @default.
• W2978482811 cites W1995237117 @default.
• W2978482811 cites W2006536282 @default.
• W2978482811 cites W2006999776 @default.
• W2978482811 cites W2011116060 @default.
• W2978482811 cites W2019428332 @default.
• W2978482811 cites W2020375093 @default.
• W2978482811 cites W2021599438 @default.
• W2978482811 cites W2032925210 @default.
• W2978482811 cites W2038611143 @default.
• W2978482811 cites W2040329915 @default.
• W2978482811 cites W2045287336 @default.
• W2978482811 cites W2051649380 @default.
• W2978482811 cites W2062811660 @default.
• W2978482811 cites W2066050897 @default.
• W2978482811 cites W2067439555 @default.
• W2978482811 cites W2069322081 @default.
• W2978482811 cites W2072877023 @default.
• W2978482811 cites W2077899541 @default.
• W2978482811 cites W2083122191 @default.
• W2978482811 cites W2089317346 @default.
• W2978482811 cites W2106696650 @default.
• W2978482811 cites W2110664937 @default.
• W2978482811 cites W2123521494 @default.
• W2978482811 cites W2128437559 @default.
• W2978482811 cites W2150819169 @default.
• W2978482811 cites W2157325254 @default.
• W2978482811 cites W2307968750 @default.
• W2978482811 cites W2319492983 @default.
• W2978482811 cites W2325451246 @default.
• W2978482811 cites W2326556890 @default.
• W2978482811 cites W2330991050 @default.
• W2978482811 cites W2333705097 @default.
• W2978482811 cites W2476681730 @default.
• W2978482811 cites W2507672151 @default.
• W2978482811 cites W2538389320 @default.
• W2978482811 cites W2556233434 @default.
• W2978482811 cites W2588619975 @default.
• W2978482811 cites W2603057204 @default.
• W2978482811 cites W2606489125 @default.
• W2978482811 cites W2606619436 @default.
• W2978482811 cites W2728532509 @default.
• W2978482811 cites W2751619001 @default.
• W2978482811 cites W2755473611 @default.
• W2978482811 cites W2767098614 @default.
• W2978482811 cites W2768702548 @default.
• W2978482811 cites W2782202459 @default.
• W2978482811 cites W2783623304 @default.
• W2978482811 cites W2803922487 @default.
• W2978482811 cites W2804146690 @default.
• W2978482811 cites W2909117814 @default.
• W2978482811 cites W2913384811 @default.
• W2978482811 cites W2924893614 @default.
• W2978482811 cites W2943515215 @default.
• W2978482811 cites W2963262695 @default.
• W2978482811 cites W2965042972 @default.
• W2978482811 cites W2965182578 @default.
• W2978482811 cites W863033760 @default.
• W2978482811 doi "https://doi.org/10.3390/molecules24193609" @default.
• W2978482811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6804187" @default.
• W2978482811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31591329" @default.
• W2978482811 hasPublicationYear "2019" @default.
• W2978482811 type Work @default.
• W2978482811 sameAs 2978482811 @default.
• W2978482811 citedByCount "34" @default.
• W2978482811 countsByYear W29784828112020 @default.
• W2978482811 countsByYear W29784828112021 @default.
• W2978482811 countsByYear W29784828112022 @default.
• W2978482811 countsByYear W29784828112023 @default.
• W2978482811 crossrefType "journal-article" @default.
• W2978482811 hasAuthorship W2978482811A5015299923 @default.
• W2978482811 hasAuthorship W2978482811A5024706803 @default.
• W2978482811 hasAuthorship W2978482811A5031903323 @default.
• W2978482811 hasAuthorship W2978482811A5037405149 @default.

• next