FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978541339> ?p ?o ?g. }

• W2978541339 abstract "Abstract The structure-specific endonuclease XPF-ERCC1 participates in multiple DNA damage repair pathways including nucleotide excision repair (NER) and inter-strand crosslink repair (ICLR). How XPF-ERCC1 is catalytically activated by DNA junction substrates is not currently understood. We report cryo-electron microscopy structures of both DNA-free and DNA-bound human XPF-ERCC1. DNA-free XPF-ERCC1 adopts an auto-inhibited conformation in which the XPF helical domain masks ERCC1 DNA-binding elements and restricts access to the XPF catalytic site. Binding of a model DNA junction separates the XPF helical and ERCC1 (HhH) 2 domains, promoting activation. Using these structural data, we propose a model for a 5’-NER incision complex involving XPF-ERCC1-XPA and a DNA junction substrate. Structure-function data suggest xeroderma pigmentosum patient mutations often compromise the structural integrity of XPF-ERCC1. Fanconi anaemia patient mutations often display substantial in-vitro activity but are resistant to activation by ICLR recruitment factor SLX4. Our data provide insights into XPF-ERCC1 architecture and catalytic activation." @default.
• W2978541339 created "2019-10-10" @default.
• W2978541339 creator A5001797587 @default.
• W2978541339 creator A5010187326 @default.
• W2978541339 creator A5022542239 @default.
• W2978541339 creator A5027628274 @default.
• W2978541339 creator A5029987103 @default.
• W2978541339 creator A5064108147 @default.
• W2978541339 creator A5070501440 @default.
• W2978541339 creator A5075652330 @default.
• W2978541339 creator A5076424245 @default.
• W2978541339 creator A5089072132 @default.
• W2978541339 date "2019-10-07" @default.
• W2978541339 modified "2023-10-17" @default.
• W2978541339 title "Cryo-EM Structures of the XPF-ERCC1 Endonuclease Reveal an Auto-Inhibited Conformation and the Basis for Activation" @default.
• W2978541339 cites W1968245004 @default.
• W2978541339 cites W1981148605 @default.
• W2978541339 cites W1992129085 @default.
• W2978541339 cites W1996372461 @default.
• W2978541339 cites W1997927846 @default.
• W2978541339 cites W2000983378 @default.
• W2978541339 cites W2010787386 @default.
• W2978541339 cites W2030534540 @default.
• W2978541339 cites W2037978116 @default.
• W2978541339 cites W2052626813 @default.
• W2978541339 cites W2056089116 @default.
• W2978541339 cites W2059186992 @default.
• W2978541339 cites W2061545358 @default.
• W2978541339 cites W2070183703 @default.
• W2978541339 cites W2080726979 @default.
• W2978541339 cites W2082398105 @default.
• W2978541339 cites W2084369408 @default.
• W2978541339 cites W2087634145 @default.
• W2978541339 cites W2097604487 @default.
• W2978541339 cites W2102265131 @default.
• W2978541339 cites W2106848851 @default.
• W2978541339 cites W2107458751 @default.
• W2978541339 cites W2110187161 @default.
• W2978541339 cites W2110936528 @default.
• W2978541339 cites W2111398476 @default.
• W2978541339 cites W2111461823 @default.
• W2978541339 cites W2111786446 @default.
• W2978541339 cites W2118619700 @default.
• W2978541339 cites W2119963779 @default.
• W2978541339 cites W2132629607 @default.
• W2978541339 cites W2142613197 @default.
• W2978541339 cites W2149500199 @default.
• W2978541339 cites W2152562710 @default.
• W2978541339 cites W2157004858 @default.
• W2978541339 cites W2163885210 @default.
• W2978541339 cites W2166424758 @default.
• W2978541339 cites W2340685884 @default.
• W2978541339 cites W2432427150 @default.
• W2978541339 cites W2564055409 @default.
• W2978541339 cites W2587625522 @default.
• W2978541339 cites W2591772585 @default.
• W2978541339 cites W2593511418 @default.
• W2978541339 cites W2602419737 @default.
• W2978541339 cites W2605284725 @default.
• W2978541339 cites W2606366720 @default.
• W2978541339 cites W2765322245 @default.
• W2978541339 cites W2786390877 @default.
• W2978541339 cites W2797631238 @default.
• W2978541339 cites W2896816499 @default.
• W2978541339 cites W2899714098 @default.
• W2978541339 cites W2902993140 @default.
• W2978541339 cites W2905715436 @default.
• W2978541339 cites W2906078895 @default.
• W2978541339 cites W2910053627 @default.
• W2978541339 cites W2916021243 @default.
• W2978541339 cites W2946483288 @default.
• W2978541339 cites W2953320394 @default.
• W2978541339 cites W2953821629 @default.
• W2978541339 cites W2954851300 @default.
• W2978541339 cites W4233279702 @default.
• W2978541339 doi "https://doi.org/10.1101/796524" @default.
• W2978541339 hasPublicationYear "2019" @default.
• W2978541339 type Work @default.
• W2978541339 sameAs 2978541339 @default.
• W2978541339 citedByCount "0" @default.
• W2978541339 crossrefType "posted-content" @default.
• W2978541339 hasAuthorship W2978541339A5001797587 @default.
• W2978541339 hasAuthorship W2978541339A5010187326 @default.
• W2978541339 hasAuthorship W2978541339A5022542239 @default.
• W2978541339 hasAuthorship W2978541339A5027628274 @default.
• W2978541339 hasAuthorship W2978541339A5029987103 @default.
• W2978541339 hasAuthorship W2978541339A5064108147 @default.
• W2978541339 hasAuthorship W2978541339A5070501440 @default.
• W2978541339 hasAuthorship W2978541339A5075652330 @default.
• W2978541339 hasAuthorship W2978541339A5076424245 @default.
• W2978541339 hasAuthorship W2978541339A5089072132 @default.
• W2978541339 hasBestOaLocation W29785413391 @default.
• W2978541339 hasConcept C104451858 @default.
• W2978541339 hasConcept C134935766 @default.
• W2978541339 hasConcept C143425029 @default.
• W2978541339 hasConcept C153911025 @default.
• W2978541339 hasConcept C2777028655 @default.
• W2978541339 hasConcept C2778378917 @default.
• W2978541339 hasConcept C2779309665 @default.
• W2978541339 hasConcept C54355233 @default.

• next