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- W2978553003 abstract "Introduction: Esophageal motor dysfunction is common in lung transplant recipients. It is not known whether motility patterns evolve over time. We sought to investigate the evolution of esophageal motor function in patients after lung transplantation. The goal of this study was to compare the high-resolution manometry (HRM) parameters on initial and subsequent examination. We also determined whether the Chicago Classification (CC) 3.0 changed on later examination. Methods: All patients who underwent lung transplantation from September 2012 - December 2014, and had more than one HRM study performed after lung transplantation, were reviewed. All patients underwent HRM evaluation using solid state HRM catheter (Sierra scientific instruments). The initial manometry was compared to the subsequent manometry in all patients. Results: A total of 14 patients fulfilled the criteria to be included in our analysis. Three (21%) patients were females and 11 (79%) were male. Mean age was 56 years (range: 24 - 72 years). Two (14%) patients had COPD and 12 (86%) had ILD. There was no statistically significant difference in the overall swallows of first and subsequent HRM in terms of mean DCI, DL, IRP, LESP and UESP (table 1). Initial HRM studies, using CC 3.0 classification, showed seven patients (50%) with normal manometry, three (21%) with ineffective esophageal motility (IEM), two (14%) with hypercontractile esophagus (HE), one (7%) with achalasia and one (7%) with esophagogastric junction outflow obstruction (EGJOO). On repeat studies, 3/7 patients with normal initial HRM had a change in their diagnosis (developed hypercontractile esophagus, IEM and EGJOO); two patients with IEM on initial HRM had a change in diagnosis (developed achalasia and normal esophageal motility); one patient with HE on initial HRM developed type III; one patient with achalasia on initial HRM developed IEM and one patient with EGJOO on initial HRM developed normal esophageal manometry. Conclusion: In our cohort of lung transplant recipients, CC 3.0 diagnosis changed on repeat manometry testing in 64% of the patients. Individual manometric parameters were variable on follow up studies as well. This data reveals that esophageal function after lung transplant can evolve. Additional investigation is needed to understand whether longitudinal changes in esophageal motility can correlate with reflux burden or graft survival.Table 1: Comparison of manometric parameters of first and second HRM studies" @default.
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- W2978553003 date "2016-10-01" @default.
- W2978553003 modified "2023-09-24" @default.
- W2978553003 title "Evolution of High-resolution Manometry Parameters in Patients Who Undergo Lung Transplantation" @default.
- W2978553003 doi "https://doi.org/10.14309/00000434-201610001-00493" @default.
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