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- W2978584562 abstract "Purpose: Previous studies have shown that gastric retention of >10% at 4 hours is indicative of delayed emptying by scintigraphy using a low fat meal (Tougas et al, Am J Gastroenterol 2000; 95:1456). Recently a multi-center study has suggested that the percent retention at 3 hours is the best individual time point for detect gastroparesis (Parkman et al, Gastroenterology 2006; 130:A-507). The aim of this study is to investigate the best time point for detection of delayed gastric emptying (GE) by gastric emptying scintigraphy using a low fat meal. Methods: We retrospectively reviewed gastric empting data previously performed on 179 patients (42F, mean age: 41 years) with gastroparesis and 41 patients (34F, mean age: 37 years) with symptoms of nausea and vomiting and normal gastric emptying assessed by gastric empting scintigraphy using a low fat meal. The gastric emptying study was performed in a standardized fashion with imaging at 0, 1, 2, 3 and 4 hours after ingestion of a 99mTc–labeled low fat meal (120 g EggBeatersn 2 pieces of bread with strawberry jam and 120 ml mater; 255kcal, 2% fat). The percent of gastric retention at 1, 2, 3 and 4 hours after meal were calculated using geometric mean and decay correction. Receiver operating characteristic (ROC) curves were generated to optimize sensitivity and specificity for differentiating gastroparetic patients from subjects with normal gastric emptying for the percent retention (%R) at 2, 3, and 4 hours imaging time. The concordance statistic (c-statistic) denoting the area under the ROC curve was used for a global measure of diagnostic utility. Results: Based on the normal range of gastric retention established at University of Kansas Medical Center, i.e., 60% or less, 28% or less, and 10% or less at 2, 3 and 4 hours, respectively, the c-statistic for%R at 4 hours (c = 0.954) is greater than that either at 2 hours (c = 0.598) or at 3 hours (c = 0.643). The currently used cutoff points for%R of 10%, 28%, and 60% at 4, 3, and 2 hours give a sensitivity and specificity of 100% and 90.9%, 47.8% and 80.7%, and 52.2% and 67.5%, respectively. Conclusions: Extending GE scintigraphy with a low fat meal from 2 to 4 hours detects more patients with delayed GE. GE data at 3 and 4 hours have advantages over 2 hours, but GE at 4 hours is the best time point for detection of delayed GE or gastroparesis in this patient population." @default.
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- W2978584562 date "2006-09-01" @default.
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- W2978584562 title "What Is the Best Time Point for Detection of Delayed Gastric Emptying by Gastric Emptying Scintigraphy?" @default.
- W2978584562 doi "https://doi.org/10.14309/00000434-200609001-00167" @default.
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