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- W2978597840 abstract "Introduction: Hidradenocarcinoma (HAC) is a rare, aggressive dermatologic malignancy of the sweat glands. It is reported in only 2/500 000 skin biopsies in the United States. The tumor has a high incidence of local and remote metastases. We report a case of HAC that was diagnosed by esophagogastroduodenoscopy (EGD). Case Presentation: A 35-year-old man who was otherwise healthy presented to our hospital complaining of severe abdominal pain and vomiting for 3 days duration. The patient reported fatigue and unintentional weight loss of 30 pounds for the past nine months. The patient denied hematemesis, hematochezia, constipation, night sweat, fever, family or personal history of peptic ulcer disease or malignancy. The patient denied a history of tobacco or alcohol use. Upon admission, vital signs were within normal limits. Physical examination was significant for moderate epigastric tenderness to palpation without rebound, guarding, or distension. Digital rectal examination was negative for gross or occult blood. A 2x2 cm mass was found in the left axilla which the patient had not previously noted. The rest of the examination was unremarkable. Laboratory findings showed normocytic anemia with a hemoglobin of 11.0mg/dl and an elevated ESR of 150mm/hr. EGD showed a duodenal nodular mass at the site of the ampulla of Vater (Figure 1). Biopsy results revealed a metastatic HAC (Figure 2). Chest computerized tomography (CT) demonstrated the axillary mass with possible lung metastases. Subsequent biopsy of the left lymph node showed poorly differentiated highly infiltrative apocrine HAC (Figure 3).Figure 1Figure 2Figure 3Patient outcome: Staging of the tumor with FDG PET-CT scan revealed widely metastatic disease with peritoneal carcinomatosis, liver, lung and gastrointestinal metastases. Patient was referred to the Oncology team and was placed on nivolumab (Opdivo®) and tamoxifen. No gastrointestinal bleeding was reported at 3 and 6 month follow-up. The patient died 7 months after treatment initiation due to septic shock, secondary to hospital acquired pneumonia. Conclusion: Hidradenocarcinoma is a rare, aggressive malignant tumor with a potential to metastasize to the gastrointestinal tract causing peptic-ulcer like symptoms. Histopathological correlation is mandatory to establish the diagnosis." @default.
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- W2978597840 date "2016-10-01" @default.
- W2978597840 modified "2023-09-27" @default.
- W2978597840 title "Gastrointestinal Hidradenocarcinoma: A Rare Location for a Sweat Gland" @default.
- W2978597840 doi "https://doi.org/10.14309/00000434-201610001-01522" @default.
- W2978597840 hasPublicationYear "2016" @default.
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