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• W2978627495 abstract "Purpose: The frequency and clinical significance of heterotopic gastric mucosa in the upper esophagus, also called inlet patch, is not known. It is thought to result in acid production causing GERD. Many histologic changes have been described in the esophageal squamous mucosa in patients with GERD such as balloon cells, basal cell hyperplasia, and intraepithelial eosinophils. The aim of this study was to assess if there were any histologic changes in esophageal squamous mucosa surrounding inlet patches as well as in the upper gastrointestinal tract. Methods: Patients from 2/2012 to 5/2013 were identified who by endoscopic appearance had an inlet patch. Biopsies were obtained from the inlet patch as well as from esophageal mucosa surrounding the inlet patch. The mucosa surrounding the inlet patch was evaluated for the presence or absence of eight previously reported reflux-associated histologic changes including dilated intercellular spaces, balloon cells, intrapapillary vessel dilation, elongated papillae, basal cell hyperplasia, acanthosis, intraepithelial eosinophils, and Langerhans cells. Use of proton pump inhibitors, presence of hiatal hernia, reflux esophagitis, Barrett's esophagus, Helicobacter pylori were also noted. Results: Thirteen patients were identified. Baseline characteristics: mean age 54 years (32-69), gender 12 males: 1 female, nearly all were Caucasian, majority reported heartburn (70%). All heterotopic gastric mucosas were oxyntic type on histologic analysis. All esophageal biopsies of mucosa surrounding the inlet patches revealed normal esophageal squamous mucosa. All histologic markers for GERD were absent. 5/13 had evidence of Barrett's esophagus, 2/13 had H. pylori, 7/13 had hiatal hernia on endoscopic evaluation, 1/13 had reflux esophagitis, and 8/13 were on proton pump inhibitor prior to endoscopy. Conclusion: Although heterotopic gastric mucosas in the esophagus are thought to produce refluxlike symptoms, there were no histopathological changes consistent with GERD identified in mucosa surrounding the inlet patch in our small pilot study. This may be attributed to the large portion of patients on acid suppression medication prior to endoscopy." @default.
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• W2978627495 date "2013-10-01" @default.
• W2978627495 modified "2023-10-17" @default.
• W2978627495 title "Are There any Histologic Changes Suggestive of Acid Exposure in the Esophageal Mucosa Surrounding Inlet Patches?" @default.
• W2978627495 doi "https://doi.org/10.14309/00000434-201310001-00091" @default.
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