Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978627790> ?p ?o ?g. }
- W2978627790 endingPage "136" @default.
- W2978627790 startingPage "129" @default.
- W2978627790 abstract "OBJECTIVES To investigate the summative effects of vascular risk factors (VRFs) on the progression of Alzheimer disease (AD). DESIGN Longitudinal follow‐up cohort study. SETTING AD patients from two teaching hospitals in Taiwan with 3‐year follow‐ups. PARTICIPANTS A total of 330 AD patients with a mean age of 80.7 years, a mean Mini‐Mental State Examination (MMSE) score 18.7, and a mean Clinical Dementia Rating Sum of Boxes (CDRSB) score of 6.9. MEASUREMENTS All patients completed a clinically functional assessment and a neuropsychological test battery at baseline and yearly follow‐ups. The VRF burden was combined into a summative VRF index at baseline (ie, having one, two, or more VRFs); VRFs included coronary heart disease, cardiac arrhythmia, hypertension, cerebrovascular disease, diabetes mellitus, obesity, smoking, and physical inactivity. The generalized estimating equation (GEE) method was used to analyze the correlations between the VRFs and longitudinal MMSE and CDRSB changes. RESULTS The results of the GEE adjusted for age, years of education, sex, disease duration, baseline MMSE score, time, apolipoprotein E (APOE) ε4 carrier status, use of medications (acetylcholinesterase inhibitors or N‐methyl‐D‐aspartate receptor antagonists), and hospitalization rates and showed that patients with more than three VRFs had more rapid cognitive decline than patients without VRFs (MMSE, P = .02; CDRSB, P = .001) as well as patients with three or fewer VRFs (MMSE, P = .009; CDRSB, P = .02). Subsequent analyses of APOE ε4 carriers with more than three VRFs also showed their more rapid cognitive decline compared with patients without VRFs (MMSE, P = .02; CDRSB, P = .001) and patients with three or fewer VRFs (MMSE, P = .009; CDRSB, P = .02), but no significant difference was found in APOE ε4 noncarriers. CONCLUSION Multiple VRFs have summative effects on the progression of AD, especially in APOE ε4 carriers. J Am Geriatr Soc 68:129–136, 2019" @default.
- W2978627790 created "2019-10-10" @default.
- W2978627790 creator A5006053247 @default.
- W2978627790 creator A5011714510 @default.
- W2978627790 creator A5028390017 @default.
- W2978627790 creator A5048016744 @default.
- W2978627790 creator A5068918212 @default.
- W2978627790 date "2019-10-06" @default.
- W2978627790 modified "2023-10-16" @default.
- W2978627790 title "Summative Effects of Vascular Risk Factors on the Progression of Alzheimer Disease" @default.
- W2978627790 cites W1525745135 @default.
- W2978627790 cites W1570302318 @default.
- W2978627790 cites W1702796904 @default.
- W2978627790 cites W1847168837 @default.
- W2978627790 cites W1968450664 @default.
- W2978627790 cites W1976203166 @default.
- W2978627790 cites W1988386882 @default.
- W2978627790 cites W1991419466 @default.
- W2978627790 cites W1991952617 @default.
- W2978627790 cites W1995118675 @default.
- W2978627790 cites W2006035554 @default.
- W2978627790 cites W2009724146 @default.
- W2978627790 cites W2014353964 @default.
- W2978627790 cites W2015202736 @default.
- W2978627790 cites W2016254773 @default.
- W2978627790 cites W2021858178 @default.
- W2978627790 cites W2027987672 @default.
- W2978627790 cites W2033728648 @default.
- W2978627790 cites W2034897558 @default.
- W2978627790 cites W2036362108 @default.
- W2978627790 cites W2045777597 @default.
- W2978627790 cites W2055268621 @default.
- W2978627790 cites W2105112406 @default.
- W2978627790 cites W2107917334 @default.
- W2978627790 cites W2111531363 @default.
- W2978627790 cites W2115017507 @default.
- W2978627790 cites W2123457140 @default.
- W2978627790 cites W2126128851 @default.
- W2978627790 cites W2128519424 @default.
- W2978627790 cites W2132842417 @default.
- W2978627790 cites W2133901138 @default.
- W2978627790 cites W2139915905 @default.
- W2978627790 cites W2145130062 @default.
- W2978627790 cites W2148196878 @default.
- W2978627790 cites W2149943549 @default.
- W2978627790 cites W2154034238 @default.
- W2978627790 cites W2158025917 @default.
- W2978627790 cites W2167510396 @default.
- W2978627790 cites W2398145977 @default.
- W2978627790 cites W2559033317 @default.
- W2978627790 cites W2612300503 @default.
- W2978627790 cites W2731775124 @default.
- W2978627790 cites W2782565874 @default.
- W2978627790 cites W2784969266 @default.
- W2978627790 cites W2791823565 @default.
- W2978627790 cites W2793548484 @default.
- W2978627790 doi "https://doi.org/10.1111/jgs.16181" @default.
- W2978627790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31587263" @default.
- W2978627790 hasPublicationYear "2019" @default.
- W2978627790 type Work @default.
- W2978627790 sameAs 2978627790 @default.
- W2978627790 citedByCount "20" @default.
- W2978627790 countsByYear W29786277902020 @default.
- W2978627790 countsByYear W29786277902021 @default.
- W2978627790 countsByYear W29786277902022 @default.
- W2978627790 countsByYear W29786277902023 @default.
- W2978627790 crossrefType "journal-article" @default.
- W2978627790 hasAuthorship W2978627790A5006053247 @default.
- W2978627790 hasAuthorship W2978627790A5011714510 @default.
- W2978627790 hasAuthorship W2978627790A5028390017 @default.
- W2978627790 hasAuthorship W2978627790A5048016744 @default.
- W2978627790 hasAuthorship W2978627790A5068918212 @default.
- W2978627790 hasBestOaLocation W29786277901 @default.
- W2978627790 hasConcept C105795698 @default.
- W2978627790 hasConcept C126322002 @default.
- W2978627790 hasConcept C164705383 @default.
- W2978627790 hasConcept C27403532 @default.
- W2978627790 hasConcept C2779077818 @default.
- W2978627790 hasConcept C2779134260 @default.
- W2978627790 hasConcept C2779483572 @default.
- W2978627790 hasConcept C33923547 @default.
- W2978627790 hasConcept C53084192 @default.
- W2978627790 hasConcept C71924100 @default.
- W2978627790 hasConceptScore W2978627790C105795698 @default.
- W2978627790 hasConceptScore W2978627790C126322002 @default.
- W2978627790 hasConceptScore W2978627790C164705383 @default.
- W2978627790 hasConceptScore W2978627790C27403532 @default.
- W2978627790 hasConceptScore W2978627790C2779077818 @default.
- W2978627790 hasConceptScore W2978627790C2779134260 @default.
- W2978627790 hasConceptScore W2978627790C2779483572 @default.
- W2978627790 hasConceptScore W2978627790C33923547 @default.
- W2978627790 hasConceptScore W2978627790C53084192 @default.
- W2978627790 hasConceptScore W2978627790C71924100 @default.
- W2978627790 hasFunder F4320321041 @default.
- W2978627790 hasFunder F4320322795 @default.
- W2978627790 hasFunder F4320323275 @default.
- W2978627790 hasFunder F4320323465 @default.
- W2978627790 hasFunder F4320326232 @default.