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- W2978633787 abstract "Abstract The discovery of small non-coding RNAs, such as miRNA and piRNA, has dramatically changed our understanding of the role RNA plays in organisms. Recent studies show that a novel small non-coding RNA generated from cleavage of tRNA or pre-tRNA, called tRNA-derived small RNA (tsRNA), serves as a new regulator of gene expression. tsRNA has been determined participate in regulating some specific physiological and pathological processes. Although knowledge regarding the biological roles of miRNA and piRNA is expanding, whether tsRNAs play similar roles remains poorly understood. Here, we review the current knowledge regarding the mechanisms of action and biological functions of tsRNAs in intracellular, extracellular and intergenerational inheritance, and highlight the potential application of tsRNAs in human diseases, and present the current problems and future research directions." @default.
- W2978633787 created "2019-10-10" @default.
- W2978633787 creator A5030684470 @default.
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- W2978633787 date "2019-10-07" @default.
- W2978633787 modified "2023-09-25" @default.
- W2978633787 title "Emerging role of a novel small non-coding regulatory RNA: tRNA-derived small RNA" @default.
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- W2978633787 doi "https://doi.org/10.1186/s41544-019-0036-7" @default.
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