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• W2978643377 endingPage "63" @default.
• W2978643377 startingPage "46" @default.
• W2978643377 abstract "Tissue-engineered graft substitutes have shown great potential to treat large bone defects. While we usually assume that therapeutic approaches developed for appendicular bone healing could be similarly translated for application in craniofacial reconstruction and vice versa, this is not necessarily accurate. In addition to those more well-known healing-associated factors, such as age, lifestyle (e.g., nutrition and smoking), preexisting disease (e.g., diabetes), medication, and poor blood supply, the developmental origins and surrounding tissue of the wound sites can largely affect the fracture healing outcome as well as designed treatments. Therefore, the strategies developed for long bone fracture repair might not be suitable or directly applicable to skull bone repair. In this review, we discuss aspects of development, healing process, structure, and tissue engineering considerations between calvarial and long bones to assist in designing the tailored bone repair strategies. We summarized, in this review, the existing body of knowledge between long bone and calvarial bone with regard to their development and healing, tissue structure, and consideration of current tissue engineering strategies. By highlighting their similarities and differences, we propose that tailored tissue engineering strategies, such as scaffold features, growth factor usage, and the source of cells for tissue or region-specific bone repair, are necessary to ensure an optimized healing outcome." @default.
• W2978643377 created "2019-10-10" @default.
• W2978643377 creator A5010476135 @default.
• W2978643377 creator A5024284108 @default.
• W2978643377 creator A5027561780 @default.
• W2978643377 creator A5073568638 @default.
• W2978643377 creator A5080696009 @default.
• W2978643377 creator A5081135426 @default.
• W2978643377 date "2020-02-01" @default.
• W2978643377 modified "2023-10-16" @default.
• W2978643377 title "Calvarial Versus Long Bone: Implications for Tailoring Skeletal Tissue Engineering" @default.
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