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• W2978653046 abstract "Purpose: Incidence of hepatocellular carcinoma (HCC) is on the rise in the US and around the world. In the US population rate of occurrence has doubled in the past two decades. The most common etiologies for HCC include viral hepatitis C and B, alcohol (ASH), non alcoholic steatohepatitis (NASH) and hemochromatosis (HC). Alcohol doubles the risk of HCC in chronic hepatitis C patients. The impact of NASH and ASH on HCC is largely unclear. Methods: A database has been created to prospectively evaluate the interactions of HCV and DM/ metabolic syndrome in a population of male US veterans. Here we present the demographic data for a consecutive case series of HCC patients and assess the prevalence of DM and alcohol abuse among veterans diagnosed with HCC. Preliminary analysis of this data is presented. Cross sectional analysis was performed on 53 veterans with diagnosis of HCC by biopsy or liver lesion with elevated AFP >500. Demographic clinical and laboratory data including viral hepatitis serologies, alcohol use, and presence of DM were evaluated. SPSS version 13 was used for the statistical analysis. Results: Of the 53 male veterans with diagnosis of HCC 50.9% were white, 18.9% were black and 22.6% were hispanic. For the entire cohort mean age (years) was 64.68 ± 2.68 (95%CI). 69.8% of patients had HCV, 57% were HBV cAb positive, while 4% had HBV sAg, 36.5% had HCV and evidence of exposure to B (cAb and/or sAg positivity), 5.8% of patients had NASH only, 20.8% had ASH only. 3.8% had HC. DM occured in 52.83% of this patient population and 64.15% of the patients had history of significant alcohol use. 32% of patients in this cohort had both DM and alcohol abuse as part of their history. Frequency of DM and/or alcohol abuse is found to be 84.9%. The mean HgbA1c among those with DM was 7.2 ± 0.61 (95%CI). Conclusions: HCC in our veteran population is mostly related to HCV. A large proportion of veterans with HCC also have alcohol abuse and DM as comorbid conditions. Further studies are needed to evaluate the impact of alcohol and diabetes on the oncogenesis in the setting of HCC. While our cohort is too small to show the statistical significance, we plan further investigations to evaluate the impact of ASH and NASH on oncogenesis in the setting of HCC, potentially modifiable contributors to this fatal disease." @default.
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• W2978653046 date "2005-09-01" @default.
• W2978653046 modified "2023-09-26" @default.
• W2978653046 title "Demographics of Hepatocellular Carcinoma and Association with Alcohol Intake and Presence of Diabetes Mellitus among US Veterans. A Cross Sectional Analysis" @default.
• W2978653046 doi "https://doi.org/10.14309/00000434-200509001-00359" @default.
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