Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978657732> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2978657732 endingPage "v315" @default.
- W2978657732 startingPage "v315" @default.
- W2978657732 abstract "Abstract Background Studies to identify predictive biomarkers of adjuvant chemotherapy with S-1 after gastrectomy in Stage II/III gastric cancer patients have been done; however, more clarity and understanding are needed. Our aim in the present study was to identify biomarkers predicting benefit due to S-1 adjuvant chemotherapy using comprehensive gene expression analysis. Methods We retrospectively analyzed 102 patients receiving adjuvant chemotherapy with S-1 and 46 patients not receiving S-1 adjuvant chemotherapy after gastrectomy for gastric cancer treatment between January 2014 and December 2016. Hierarchical clustering analysis was performed based on the gene expression data obtained using DNA microarrays. Differentially expressed genes (DEGs) were identified using thresholds of absolute fold changes (FCs) of > 4.0 and a false discovery rate (FDR) P value of Results Hierarchical clustering analysis in patients treated with S-1 adjuvant chemotherapy revealed two clusters with favorable and unfavorable survival outcomes. We identified 147 upregulated DEGs and 192 downregulated DEGs in the favorable outcome group. GO analysis to identify significantly upregulated genes showed enrichment in immune-related genes and GO terms. Upregulation of these immune-related genes was not associated with survival in patients not receiving S-1 adjuvant chemotherapy. Conclusions The upregulation and enrichment of immune-related genes and GO terms may be a predictive biomarker in patients who would benefit from adjuvant S-1 chemotherapy to treat Stage II/III gastric cancer. Legal entity responsible for the study The authors. Funding Has not received any funding. Disclosure M. Terashima: Honoraria (self): Taiho; Honoraria (self): Chugai; Honoraria (self): Yakult; Honoraria (self): ONo; Honoraria (self): BMS; Honoraria (self): Eli-Lilly; Honoraria (self): Takeda; Honoraria (self): Daiichi-Sankyo; Honoraria (self): Kyowa Hakko Kirin; Honoraria (self): Nihon Kayaku; Honoraria (self): Pfizer. All other authors have declared no conflicts of interest." @default.
- W2978657732 created "2019-10-10" @default.
- W2978657732 creator A5003130075 @default.
- W2978657732 creator A5005598571 @default.
- W2978657732 creator A5008198522 @default.
- W2978657732 creator A5014271968 @default.
- W2978657732 creator A5023602886 @default.
- W2978657732 creator A5026555298 @default.
- W2978657732 creator A5032409490 @default.
- W2978657732 creator A5051756868 @default.
- W2978657732 creator A5066643427 @default.
- W2978657732 creator A5066668790 @default.
- W2978657732 creator A5069631984 @default.
- W2978657732 creator A5076314944 @default.
- W2978657732 creator A5078583769 @default.
- W2978657732 creator A5080766585 @default.
- W2978657732 date "2019-10-01" @default.
- W2978657732 modified "2023-09-28" @default.
- W2978657732 title "Prediction of S-1 adjuvant chemotherapy efficacy in stage II/III gastric cancer treatment based on comprehensive gene expression analysis" @default.
- W2978657732 doi "https://doi.org/10.1093/annonc/mdz247.147" @default.
- W2978657732 hasPublicationYear "2019" @default.
- W2978657732 type Work @default.
- W2978657732 sameAs 2978657732 @default.
- W2978657732 citedByCount "1" @default.
- W2978657732 countsByYear W29786577322021 @default.
- W2978657732 crossrefType "journal-article" @default.
- W2978657732 hasAuthorship W2978657732A5003130075 @default.
- W2978657732 hasAuthorship W2978657732A5005598571 @default.
- W2978657732 hasAuthorship W2978657732A5008198522 @default.
- W2978657732 hasAuthorship W2978657732A5014271968 @default.
- W2978657732 hasAuthorship W2978657732A5023602886 @default.
- W2978657732 hasAuthorship W2978657732A5026555298 @default.
- W2978657732 hasAuthorship W2978657732A5032409490 @default.
- W2978657732 hasAuthorship W2978657732A5051756868 @default.
- W2978657732 hasAuthorship W2978657732A5066643427 @default.
- W2978657732 hasAuthorship W2978657732A5066668790 @default.
- W2978657732 hasAuthorship W2978657732A5069631984 @default.
- W2978657732 hasAuthorship W2978657732A5076314944 @default.
- W2978657732 hasAuthorship W2978657732A5078583769 @default.
- W2978657732 hasAuthorship W2978657732A5080766585 @default.
- W2978657732 hasBestOaLocation W29786577321 @default.
- W2978657732 hasConcept C121608353 @default.
- W2978657732 hasConcept C126322002 @default.
- W2978657732 hasConcept C143998085 @default.
- W2978657732 hasConcept C146357865 @default.
- W2978657732 hasConcept C151730666 @default.
- W2978657732 hasConcept C2776694085 @default.
- W2978657732 hasConcept C2777863537 @default.
- W2978657732 hasConcept C3018227240 @default.
- W2978657732 hasConcept C530470458 @default.
- W2978657732 hasConcept C71924100 @default.
- W2978657732 hasConcept C86803240 @default.
- W2978657732 hasConceptScore W2978657732C121608353 @default.
- W2978657732 hasConceptScore W2978657732C126322002 @default.
- W2978657732 hasConceptScore W2978657732C143998085 @default.
- W2978657732 hasConceptScore W2978657732C146357865 @default.
- W2978657732 hasConceptScore W2978657732C151730666 @default.
- W2978657732 hasConceptScore W2978657732C2776694085 @default.
- W2978657732 hasConceptScore W2978657732C2777863537 @default.
- W2978657732 hasConceptScore W2978657732C3018227240 @default.
- W2978657732 hasConceptScore W2978657732C530470458 @default.
- W2978657732 hasConceptScore W2978657732C71924100 @default.
- W2978657732 hasConceptScore W2978657732C86803240 @default.
- W2978657732 hasLocation W29786577321 @default.
- W2978657732 hasOpenAccess W2978657732 @default.
- W2978657732 hasPrimaryLocation W29786577321 @default.
- W2978657732 hasRelatedWork W167319750 @default.
- W2978657732 hasRelatedWork W1987468340 @default.
- W2978657732 hasRelatedWork W2048236688 @default.
- W2978657732 hasRelatedWork W2389855711 @default.
- W2978657732 hasRelatedWork W2416023710 @default.
- W2978657732 hasRelatedWork W2418004859 @default.
- W2978657732 hasRelatedWork W2977489532 @default.
- W2978657732 hasRelatedWork W3029632585 @default.
- W2978657732 hasRelatedWork W4254366463 @default.
- W2978657732 hasRelatedWork W4285048480 @default.
- W2978657732 hasVolume "30" @default.
- W2978657732 isParatext "false" @default.
- W2978657732 isRetracted "false" @default.
- W2978657732 magId "2978657732" @default.
- W2978657732 workType "article" @default.