Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978665335> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2978665335 endingPage "S78" @default.
- W2978665335 startingPage "S77" @default.
- W2978665335 abstract "Introduction: Ketamine is a noncompetitive NMDA receptor antagonist that is still widely used as a dissociative anesthetic agent as well as a recreational hallucinogenic drug. There is now emerging evidence that ketamine is associated with GI symptoms, abnormal liver function tests, and biliary tract abnormalities. A 19-year-old female presented with abdominal pain, hematuria, and fever for 1 day. She denied any history of drug abuse. Vital signs were within normal limits and physical revealed tenderness on the lower abdominal quadrants. Labs were significant for a ALP of 559 and ALT of 124. CT showed b/l hydroureteronephrosis as well as extra- and intrahepatic ductal dilatation up to 11 mm. Patient was started on antibiotics for UTI, and MRCP confirmed the biliary dilatation. Two unlabeled vials were found in her belongings and she admitted to using ketamine for many months.Table 1Patient progressed well and was discharged with follow-up with an addiction specialist. A literature search revealed 10 other cases with limited cases in the United States. The exact mechanism remains unknown, although it has been postulated that it is due to either direct actions on the biliary smooth muscles or central action. Studies have shown that ketamine dilates cerebral arteries by acting as a calcium antagonist. It is possible that this effect also extends to the biliary tree smooth muscle, thus causing biliary dilatation. Another hypothesis includes the dorsal motor nucleus of vagus (DMV), which has efferent fibers that project to the gallbladder. Injection of NMDA into the DMV increases gallbladder motility and its effect can be abolished following the application of ketamine in animal studies. These manifestations may be fully reversible with abstinence despite a number of the reported cases having ERCP performed. Clinicians should be aware of biliary abnormalities as a possible consequence of ketamine, especially in light of increased prevalence of ketamine abuse and its emerging role as an adjunct to opioids in cancer patients." @default.
- W2978665335 created "2019-10-10" @default.
- W2978665335 creator A5018109140 @default.
- W2978665335 creator A5035207261 @default.
- W2978665335 creator A5070599734 @default.
- W2978665335 creator A5083368310 @default.
- W2978665335 date "2014-10-01" @default.
- W2978665335 modified "2023-09-26" @default.
- W2978665335 title "Ketamine-Induced Biliary Ductal Dilatation: A Case Report and Review of Literature" @default.
- W2978665335 doi "https://doi.org/10.14309/00000434-201410002-00250" @default.
- W2978665335 hasPublicationYear "2014" @default.
- W2978665335 type Work @default.
- W2978665335 sameAs 2978665335 @default.
- W2978665335 citedByCount "0" @default.
- W2978665335 crossrefType "journal-article" @default.
- W2978665335 hasAuthorship W2978665335A5018109140 @default.
- W2978665335 hasAuthorship W2978665335A5035207261 @default.
- W2978665335 hasAuthorship W2978665335A5070599734 @default.
- W2978665335 hasAuthorship W2978665335A5083368310 @default.
- W2978665335 hasConcept C126322002 @default.
- W2978665335 hasConcept C2775982439 @default.
- W2978665335 hasConcept C2776629433 @default.
- W2978665335 hasConcept C2776641081 @default.
- W2978665335 hasConcept C2777148285 @default.
- W2978665335 hasConcept C2777891700 @default.
- W2978665335 hasConcept C2778807096 @default.
- W2978665335 hasConcept C2780354107 @default.
- W2978665335 hasConcept C2780795376 @default.
- W2978665335 hasConcept C2780970735 @default.
- W2978665335 hasConcept C42219234 @default.
- W2978665335 hasConcept C71924100 @default.
- W2978665335 hasConcept C98274493 @default.
- W2978665335 hasConceptScore W2978665335C126322002 @default.
- W2978665335 hasConceptScore W2978665335C2775982439 @default.
- W2978665335 hasConceptScore W2978665335C2776629433 @default.
- W2978665335 hasConceptScore W2978665335C2776641081 @default.
- W2978665335 hasConceptScore W2978665335C2777148285 @default.
- W2978665335 hasConceptScore W2978665335C2777891700 @default.
- W2978665335 hasConceptScore W2978665335C2778807096 @default.
- W2978665335 hasConceptScore W2978665335C2780354107 @default.
- W2978665335 hasConceptScore W2978665335C2780795376 @default.
- W2978665335 hasConceptScore W2978665335C2780970735 @default.
- W2978665335 hasConceptScore W2978665335C42219234 @default.
- W2978665335 hasConceptScore W2978665335C71924100 @default.
- W2978665335 hasConceptScore W2978665335C98274493 @default.
- W2978665335 hasLocation W29786653351 @default.
- W2978665335 hasOpenAccess W2978665335 @default.
- W2978665335 hasPrimaryLocation W29786653351 @default.
- W2978665335 hasRelatedWork W1529854644 @default.
- W2978665335 hasRelatedWork W179904465 @default.
- W2978665335 hasRelatedWork W1970578897 @default.
- W2978665335 hasRelatedWork W2018217527 @default.
- W2978665335 hasRelatedWork W2038820350 @default.
- W2978665335 hasRelatedWork W2049492560 @default.
- W2978665335 hasRelatedWork W2335140123 @default.
- W2978665335 hasRelatedWork W2410938844 @default.
- W2978665335 hasRelatedWork W2462983242 @default.
- W2978665335 hasRelatedWork W91246356 @default.
- W2978665335 hasVolume "109" @default.
- W2978665335 isParatext "false" @default.
- W2978665335 isRetracted "false" @default.
- W2978665335 magId "2978665335" @default.
- W2978665335 workType "article" @default.