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- W2978691818 abstract "Prostate specific membrane antigen (PSMA) is a pro-angiogenic cell-surface protease that we previously demonstrated regulates blood vessel formation in a laminin and integrin b1-dependent manner. Here, we examine the principal mechanism of PSMA activation of integrin b1. We show that digesting laminin sequentially with recom- binant matrix metalloprotease-2 (MMP-2) and PSMA generates small peptides that enhance endothelial cell adhesion and migration in vitro. We also provide evidence that these laminin peptides activate adhesion via integrin a6b1 and focal adhesion kinase. Using an in vivo Matrigel implant assay, we show that these MMP/PSMA-derived laminin peptides also increase angiogenesis in vivo. Together, our results reveal a novel mechanism of PSMA activation of angiogenesis by processing laminin down- stream of MMP-2." @default.
- W2978691818 created "2019-10-10" @default.
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- W2978691818 date "2013-01-01" @default.
- W2978691818 modified "2023-09-27" @default.
- W2978691818 title "Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2 Rebecca E. ConwayKyle JoinerAlex PattersonDavid Bourgeois • Robert RamppBenjamin C. HannahSamantha McReynoldsJohn M. Elder • Hannah GilfilenLinda H. Shapiro" @default.
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