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- W2978708928 abstract "Summary Cellular diversity in tumors is a key factor for therapeutic failures and lethal outcomes of solid malignancies. Here, we determined the single-cell transcriptomic landscape of liver cancer biospecimens from 19 patients. We found varying degrees of heterogeneity in malignant cells within and between tumors and diverse landscapes of tumor microenvironment (TME). Strikingly, tumors with higher transcriptomic diversity were associated with patient's worse overall survival. We found a link between hypoxia-dependent vascular endothelial growth factor expression in tumor diversity and TME polarization. Moreover, T cells from higher heterogeneous tumors showed lower cytolytic activities. Consistent results were found using bulk genomic and transcriptomic profiles of 765 liver tumors. Our results offer insight into the diverse ecosystem of liver cancer and its impact on patient prognosis." @default.
- W2978708928 created "2019-10-10" @default.
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- W2978708928 date "2019-10-01" @default.
- W2978708928 modified "2023-10-18" @default.
- W2978708928 title "Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer" @default.
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- W2978708928 doi "https://doi.org/10.1016/j.ccell.2019.08.007" @default.
- W2978708928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6801104" @default.
- W2978708928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31588021" @default.
- W2978708928 hasPublicationYear "2019" @default.
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