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- W2978769764 abstract "Objective To investigate the clinical and immunological features of late-onset myasthenia gravis(MG).Methods One hundred and seventy-four MG patients were divided into three groups:late-onset MG without thymoma(LOMG),early-onset MG without thymoma(EOMG) and MG with thymoma(MGT).Serum levels of acetylcholine receptor antibody(AChRAb),presynaptic membrane receptor antibody(PrSMAb),Titin antibody(TitinAb) and ryanodine receptor antibody(RyRAb) were detected in 174 MG patients and 56 normal controls(NT).Peripheral blood mononuclear cells were cultured after stimulated by ConA and AChR and IFN-γ and IL-10 levels in supernatant were examined.The population of CD4+ CD25+ Treg cells was measured by flow cytometry.Results Clinical scores of myasthenia and incidence rate of crisis in 46 LOMG cases were lower than those of EOMG and MGT groups.Serum TitinAb levels of LOMG group were higher than those of EOMG and NC groups(P0.01).Serum AChRAb and RyRAb levels in LOMV were lower than those of MGT group.There was no statistic difference in serum PrSMAb levels of three MG groups.Recurrence rate of LOMG group was lower than that of EOMG and MGT groups.Higher TitinAb levels indicated higher frequency of recurrence in LOMG group.The population of CD4+ CD25+ Treg cells and IL-10 levels in supernatant of LOMV after stimulation were lower than those of NC group.Conclusion There were higher serum TitinAb levels and lower rate of recurrence in LOMG group.Serum TitinAb levels are significantly correlated with course of disease and may serve as a risk factor for recurrence.The decrease of CD4+ CD25+ Treg cells may be related to the pathogenesis of LOMG." @default.
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- W2978769764 date "2007-01-01" @default.
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- W2978769764 title "The clinical and immunological observation of late-onset myasthenia gravis" @default.
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