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- W2978794310 abstract "Objective: To explore the effective mechanism of Schisandra fruit and Earthworm decoction on asthma.Methods:Forty-eight guinea pigs were randomly divided into six groups: the control group,the model group,the dexamethasone group,the Xiaoqinglongtang group,the schisandra fruit and earthworm decoction large and small dosage groups,8guinea pigs in each group. The guinea pigs were sensitized with 10% ovalbumin (OVA) by a combination of intraperitional injection and repeated with 1% OVA intranasal challenge to establish asthma model. The level of serum interleukine-4 (IL-4) was determined by double antibody sandwich ELISA method with the guinea pigs IL-4 kit. Results: The model guinea pigs group repeated with OVA intranasal challenge moved about decreasing,reaction retardation,lustre of coat of hair lost,tachypnea and dyspneic respiration,but other groups were a good state. The assay of serum IL-4 in large dosage group of Schisandra fluit and Earthworm decoction (9.27±0.86) pg·ml-1,small dosage group of Schisandra fluit and Earthworm decoction (10.77±1.17) pg·ml-1 and dexamethasone group (9.40±2.91) pg.ml-1 was significantly decreased as compared to the model group (13.37±1.86) pg·ml-1 (all P0.01). And xiaoqinglong tang group (10.94±1.30)pg·ml-1 was significantly decreased as compared to the model group ,too(P0.05).There was no difference among the Schisandra fruit and Earthworm decoction groups,dexamethasone group,xiaoqinglong tang group and control group (10.45±0.62) (all P0.05).Conclusion: It was demonstrated that Schisandra fruit and Earthworm decoction can reduce the level of serum IL-4 in asthmatic guinea pigs. This might be an important cause that the decoction can inhibit inflammatory media to release and treat airway inflammation." @default.
- W2978794310 created "2019-10-10" @default.
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- W2978794310 date "2007-01-01" @default.
- W2978794310 modified "2023-09-26" @default.
- W2978794310 title "Effect of Schisandra Fruit and Earthworm Decoction on Serum Interleukine-4 in Experimental Asthma Guinea Pigs" @default.
- W2978794310 hasPublicationYear "2007" @default.
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