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• W2978795711 abstract "Purpose: Many patients who suffer from irritable bowel syndrome (IBS) report adverse reactions to foods and use diet restriction and food avoidance as a way to cope with their symptoms. Diet restriction reduces pain associated with eating but repeated fasting can also cause motility disturbances (Zipfel et al. Autonomic Neurosecience 2006) which can possibly increase other IBS symptoms such as constipation and bloating. The aim of the proposed pilot study is to investigate if motility disturbances are more common in IBS patients who habitually restrict their diets versus those who do not. Methods: Subjects were 8 IBS patients who habitually restrict their diet (defined as not eating ≧4 hours while hungry to control symptoms, ≧1 day/week, for at least 6 months; Patients who were trying to lose ≧ 5 lbs were excluded) and 6 IBS patients without diet restriction (Ages range 15-21, Mean=19.5; 69.2% female). Methods: Whole gut transit time was measured by radiopaque markers, gastric sensitivity was measured by water load test (drinking max of 800 ml of water in 5 minutes or until full) and an electrogastrogram was obtained 15 min before the water load test and 30 minutes postprandially. Results: Whole gut transit tended to be slower in the restrictors (M=51.0±23 hours) versus the non-restrictors (M=37.0±19 hours). Restrictors tolerated less water until feeling full (M=464.4±107ml) than non-restrictors (M=545±178ml). Bradygastria, tachygastria or mixed dysrythmias were found in 62.5% of restrictors and 66.6% of non-restrictors. None of these differences were significant due to small sample size. Conclusion: Initial results suggest that repeated diet restriction is associated with slower transit time and increased gastric sensitivity but not with abnormal gastric myoelectrical activity. A sample of N=72 (transit time) to N=102 (gastric sensitivity) is needed for 80% power. It remains to be determined if changes in GI physiology are also associated with changes in symptoms. [Supported by a clinical research award from the American College of Gastroenterology and UL1RR025747]." @default.
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• W2978795711 date "2011-10-01" @default.
• W2978795711 modified "2023-10-18" @default.
• W2978795711 title "Diet Restriction May Be Associated with Disturbances in GI Physiology in Adolescents with Irritable Bowel Syndrome: A Pilot Study" @default.
• W2978795711 doi "https://doi.org/10.14309/00000434-201110002-01347" @default.
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