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• W2978809715 abstract "Objective: Myocardial Perfusion Imaging (MPI) with radiotracers is an integral component in evaluation of the patients with known or suspected coronary artery diseases (CAD). 99mTc-Sestamibi and 99mTc-Tetrofosmin are commercial radiopharmaceuticals for MPI by single photon-emission computed tomography (SPECT). Despite their widespread clinical applications, they do not meet the requirements of an ideal perfusion imaging agent due to their inability to linearly track the regional myocardial blood flow rate at >2.5 mL/min/g. With tremendous development of CZT-based SPECT cameras over the past several years, the nuclear cardiology community has been calling for better perfusion radiotracers with improved extraction and biodistribution properties. Methods: This review will summarize recent research efforts on new cationic and neutral 99mTc radiotracers for SPECT MPI. The goal of these efforts is to develop a 99mTc radiotracer that can be used to detect perfusion defects at rest or under stress, determine the regional myocardial blood flow, and measure the perfusion and left ventricular function. Results: The advantage of cationic radiotracers (e.g. 99mTc-Sestamibi) is their long myocardial retention because of the positive molecular charge and fast liver clearance kinetics. 99mTc-Teboroxime derivatives have a high initial heart uptake (high first-pass extraction fraction) due to their neutrality. 99mTc- 3SPboroxime is the most promising radiotracer for future clinical translation considering its initial heart uptake, myocardial retention time, liver clearance kinetics, heart/liver ratios and SPECT image quality. Conclusion: 99mTc-3SPboroximine is an excellent example of perfusion radiotracers, the heart uptake of which is largely relies on the regional blood flow. It is possible to use 99mTc-3SPboroximine for detection of perfusion defect(s), accurate quantification and determination of regional blood flow rate. Development of such a 99mTc radiotracer is of great clinical benefit for accurate diagnosis of CAD and assessing the risk of future hard events (e.g. heart attack and sudden death) in cardiac patients." @default.
• W2978809715 created "2019-10-10" @default.
• W2978809715 creator A5000979147 @default.
• W2978809715 creator A5030744752 @default.
• W2978809715 date "2019-10-01" @default.
• W2978809715 modified "2023-09-23" @default.
• W2978809715 title "New 99mTc Radiotracers for Myocardial Perfusion Imaging by SPECT" @default.
• W2978809715 cites W1533728986 @default.
• W2978809715 cites W1555946094 @default.
• W2978809715 cites W1603298572 @default.
• W2978809715 cites W1964948211 @default.
• W2978809715 cites W1969567631 @default.
• W2978809715 cites W1970671564 @default.
• W2978809715 cites W1974884958 @default.
• W2978809715 cites W1975509356 @default.
• W2978809715 cites W1978622275 @default.
• W2978809715 cites W1978803755 @default.
• W2978809715 cites W1985277575 @default.
• W2978809715 cites W1986477156 @default.
• W2978809715 cites W1986594368 @default.
• W2978809715 cites W1987900390 @default.
• W2978809715 cites W1988033181 @default.
• W2978809715 cites W1992232863 @default.
• W2978809715 cites W1996683540 @default.
• W2978809715 cites W1997155231 @default.
• W2978809715 cites W1999065263 @default.
• W2978809715 cites W1999477893 @default.
• W2978809715 cites W1999729716 @default.
• W2978809715 cites W2004296825 @default.
• W2978809715 cites W2004947512 @default.
• W2978809715 cites W2007152889 @default.
• W2978809715 cites W2007853043 @default.
• W2978809715 cites W2013974259 @default.
• W2978809715 cites W2017256807 @default.
• W2978809715 cites W2017745269 @default.
• W2978809715 cites W2030542269 @default.
• W2978809715 cites W2037009710 @default.
• W2978809715 cites W2037869820 @default.
• W2978809715 cites W2042207877 @default.
• W2978809715 cites W2048443954 @default.
• W2978809715 cites W2051055559 @default.
• W2978809715 cites W2051180338 @default.
• W2978809715 cites W2053743340 @default.
• W2978809715 cites W2056798637 @default.
• W2978809715 cites W2061040105 @default.
• W2978809715 cites W2062371642 @default.
• W2978809715 cites W2067296336 @default.
• W2978809715 cites W2069028617 @default.
• W2978809715 cites W2070043039 @default.
• W2978809715 cites W2071611167 @default.
• W2978809715 cites W2071712064 @default.
• W2978809715 cites W2074783693 @default.
• W2978809715 cites W2075344979 @default.
• W2978809715 cites W2075623165 @default.
• W2978809715 cites W2077273069 @default.
• W2978809715 cites W2078717364 @default.
• W2978809715 cites W2080605182 @default.
• W2978809715 cites W2081998696 @default.
• W2978809715 cites W2087942362 @default.
• W2978809715 cites W2096309636 @default.
• W2978809715 cites W2097604670 @default.
• W2978809715 cites W2101293566 @default.
• W2978809715 cites W2104200131 @default.
• W2978809715 cites W2104410390 @default.
• W2978809715 cites W2107892208 @default.
• W2978809715 cites W2108525359 @default.
• W2978809715 cites W2111501638 @default.
• W2978809715 cites W2115944704 @default.
• W2978809715 cites W2121521155 @default.
• W2978809715 cites W2125856951 @default.
• W2978809715 cites W2126624259 @default.
• W2978809715 cites W2135581873 @default.
• W2978809715 cites W2139143114 @default.
• W2978809715 cites W2144916644 @default.
• W2978809715 cites W2151685421 @default.
• W2978809715 cites W2152024809 @default.
• W2978809715 cites W2152682919 @default.
• W2978809715 cites W2161555101 @default.
• W2978809715 cites W2167044450 @default.
• W2978809715 cites W2169151182 @default.
• W2978809715 cites W2312330878 @default.
• W2978809715 cites W2324358101 @default.
• W2978809715 cites W2332458859 @default.
• W2978809715 cites W2345734502 @default.
• W2978809715 cites W2531547458 @default.
• W2978809715 cites W2559315288 @default.
• W2978809715 cites W2618012978 @default.
• W2978809715 cites W2769273321 @default.
• W2978809715 cites W319135923 @default.
• W2978809715 cites W4237192581 @default.
• W2978809715 cites W43961670 @default.
• W2978809715 doi "https://doi.org/10.2174/1874471012666190206102214" @default.
• W2978809715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30727939" @default.
• W2978809715 hasPublicationYear "2019" @default.
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