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- W2978818462 abstract "Objective: To observe the effect of different prescriptions of acupoints on morphological changes in rats with experimental acute injury of gastric mucosa(AIGM). Methods: 72 Wistar rats anesthetized with pentobarbital (40~50 mg/kg) were randomized into control group (n=6), model group, Zusanli group, Zusanli+Neiguan group, Zusanli +Zhongwan group and Zusanli +Neiguan +Zhongwan group. The last 5 groups were further divided into immediate subgroups, gastric samples were taken immediately after electroacupuncture (EA) treatment and 8 hr-subgroups (samples were taken 8 hours after EA), with 6 cases being in each subgroup. Acute gastric injury model was established by intragastric perfusion of absolute ethyl alcohol (1 mL). Bilateral Zusanli (ST 36), bilateral Neiguan (PC 6) and Zhongwan (CV 12) were punctured and stimulated electrically with frequency 30 Hz, 10~20 V and duration of 10 min. At the end of each experiment, the rat was killed for taking out the whole stomach that was embedded with paraffin and then sectioned and stained with HE. The sections of the stomach were observed under light microscope and electronic microscope for analyzing changes of the injured gastric mucosa. Results: ① After administration of alcohol, gastric mucosal injury was apparent in every subgroups compared with control group, but the injury degrees in every acupuncture subgroup were significantly lighter than that of model subgroups (P0.05~0.001). ② Among the different acupoint prescription groups, the injured severity of Zusanli +Neiguan +Zhongwan group was lightest under both light microscope and electronic microscope (no obvious swelling of the mitochondria, regular arrangement of the mitochondria crest and the endoplasmic reticulum without dilation). Conclusion: Acupuncture treatment has a protective action on alcohol induced injury of the gastric mucosa, and the prescription of Zusanli +Neiguan +Zhongwan may be used as the basic prescription for treating gastric diseases in clinic." @default.
- W2978818462 created "2019-10-10" @default.
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- W2978818462 date "2002-01-01" @default.
- W2978818462 modified "2023-09-25" @default.
- W2978818462 title "Effects of Different Acupoint Recipes on Morphological Changes of Gastric Mucosa in Rats with Acute Gastric Injury" @default.
- W2978818462 hasPublicationYear "2002" @default.
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