FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978846144> ?p ?o ?g. }

• W2978846144 endingPage "S467" @default.
• W2978846144 startingPage "S467" @default.
• W2978846144 abstract "Purpose: Rectal hyposensitivity (RH) may contribute to the pathogenesis of fecal incontinence and constipation, but the underlying neurobiologic mechanisms, and more specifically the integrity of peripheral lumbospinal nerves in RH is unknown. Aim: To investigate anal and rectal motor evoked potentials after translumbar and transsacral magnetic stimulation and sensory thresholds after electrical stimulation in subjects with RH and healthy controls. Methods: Subjects with RH defined as abnormally prolonged sensory thresholds for first sensation, desire or urgency to defecate (during rectal balloon distention) were tested by magnetic stimulations, performed with a Cadwell Focalpoint Coil™ (9-cm) placed over the right and left of midline at L3-L4 and S1-S3 levels using 80–100% intensity. A novel anorectal probe containing 2 pairs of bipolar steel ring electrodes (Koningsberg, CA) was used to record motor evoked potentials (MEPs); namely lumbo-anal (TL-aMEP), lumbo-rectal (TL-rMEP), the sacro-anal (TS-aMEP), sacro-rectal (TS-rMEP). Pudendal nerve latency test and rectal sensory thresholds after electrical stimulation were also performed. Student t-test and Spearman's correlation analyses were performed. Results: Thirty-eight subjects with RH (M/F 8/30, mean age 40.2 ± 13.7 yrs) were enrolled. Presenting symptoms were constipation (N = 29) or fecal incontinence (N = 9). Sixteen patients had history of spinal cord injury. Fourteen healthy subjects (M/F 5/9, mean age 42.9 ± 10.0 yrs) served as controls. The bilateral lumbo-anal (TL-aMEP), lumbo-rectal (TL-rMEP), sacro-anal (TS-aMEP), and sacro-rectal (TS-rMEP) motor evoked potentials in subjects with RH were significantly prolonged compared to controls (Table (mean ± 95%CI). After electrical stimulation, the rectal sensory thresholds for first sensation in mA (31 ± 4.37, 21 ± 2.79 (P= 0.026)) and for pain (72 ± 6.22, 46 ± 4.96, P= 0.013) were significantly prolonged compared to healthy controls. PNTML was prolonged bilaterally (P < 0.01) in RH subjects compared to controls. However, correlation between PNTML and MEPs were inconsistent (r ranged from −0.1–0.7).TableConclusion: Subjects with RH demonstrate prolonged motor evoked potentials of the peripheral lumbo-sacral spinal nerves bilaterally indicating that abnormal sensory perception is associated with significant neuropathy of these nerves. Thus, these patients may have both afferent and efferent neurovisceral dysfunction. The inconsistent correlation between PNTML and MEP's suggest that different neurologic pathways may be involved in the pathogenesis of RH. Translumbar and transsacral MEPs provide an objective tool for quantifying the presence of and severity of RH in patients with anal and rectal neuropathy." @default.
• W2978846144 created "2019-10-10" @default.
• W2978846144 creator A5011162403 @default.
• W2978846144 creator A5054091135 @default.
• W2978846144 creator A5075242997 @default.
• W2978846144 creator A5077749812 @default.
• W2978846144 creator A5091863519 @default.
• W2978846144 creator A5070804334 @default.
• W2978846144 date "2008-09-01" @default.
• W2978846144 modified "2023-09-26" @default.
• W2978846144 title "Translumbar and Transsacral Motor Evoked Potentials in Patients with Rectal Hyposensitivity" @default.
• W2978846144 doi "https://doi.org/10.14309/00000434-200809001-01195" @default.
• W2978846144 hasPublicationYear "2008" @default.
• W2978846144 type Work @default.
• W2978846144 sameAs 2978846144 @default.
• W2978846144 citedByCount "0" @default.
• W2978846144 crossrefType "journal-article" @default.
• W2978846144 hasAuthorship W2978846144A5011162403 @default.
• W2978846144 hasAuthorship W2978846144A5054091135 @default.
• W2978846144 hasAuthorship W2978846144A5070804334 @default.
• W2978846144 hasAuthorship W2978846144A5075242997 @default.
• W2978846144 hasAuthorship W2978846144A5077749812 @default.
• W2978846144 hasAuthorship W2978846144A5091863519 @default.
• W2978846144 hasConcept C103486182 @default.
• W2978846144 hasConcept C108797546 @default.
• W2978846144 hasConcept C126322002 @default.
• W2978846144 hasConcept C130093455 @default.
• W2978846144 hasConcept C15744967 @default.
• W2978846144 hasConcept C169760540 @default.
• W2978846144 hasConcept C24998067 @default.
• W2978846144 hasConcept C2776813522 @default.
• W2978846144 hasConcept C2779607992 @default.
• W2978846144 hasConcept C2781074409 @default.
• W2978846144 hasConcept C2781112942 @default.
• W2978846144 hasConcept C71924100 @default.
• W2978846144 hasConcept C90924648 @default.
• W2978846144 hasConceptScore W2978846144C103486182 @default.
• W2978846144 hasConceptScore W2978846144C108797546 @default.
• W2978846144 hasConceptScore W2978846144C126322002 @default.
• W2978846144 hasConceptScore W2978846144C130093455 @default.
• W2978846144 hasConceptScore W2978846144C15744967 @default.
• W2978846144 hasConceptScore W2978846144C169760540 @default.
• W2978846144 hasConceptScore W2978846144C24998067 @default.
• W2978846144 hasConceptScore W2978846144C2776813522 @default.
• W2978846144 hasConceptScore W2978846144C2779607992 @default.
• W2978846144 hasConceptScore W2978846144C2781074409 @default.
• W2978846144 hasConceptScore W2978846144C2781112942 @default.
• W2978846144 hasConceptScore W2978846144C71924100 @default.
• W2978846144 hasConceptScore W2978846144C90924648 @default.
• W2978846144 hasLocation W29788461441 @default.
• W2978846144 hasOpenAccess W2978846144 @default.
• W2978846144 hasPrimaryLocation W29788461441 @default.
• W2978846144 hasRelatedWork W1567088046 @default.
• W2978846144 hasRelatedWork W1959438357 @default.
• W2978846144 hasRelatedWork W19659503 @default.
• W2978846144 hasRelatedWork W1995588273 @default.
• W2978846144 hasRelatedWork W2007724078 @default.
• W2978846144 hasRelatedWork W2045394247 @default.
• W2978846144 hasRelatedWork W2047144589 @default.
• W2978846144 hasRelatedWork W2298539552 @default.
• W2978846144 hasRelatedWork W2324530059 @default.
• W2978846144 hasRelatedWork W2574020424 @default.
• W2978846144 hasVolume "103" @default.
• W2978846144 isParatext "false" @default.
• W2978846144 isRetracted "false" @default.
• W2978846144 magId "2978846144" @default.
• W2978846144 workType "article" @default.