FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978877951> ?p ?o ?g. }

• W2978877951 endingPage "S605" @default.
• W2978877951 startingPage "S604" @default.
• W2978877951 abstract "Introduction: The overall incidence of early onset CRC has increased at a rate of 1.5-2% per year in the US and Europe. Younger CRC patients (age < 50) are more likely to present with advanced stage and have higher risk of recurrence, however it is unclear how these differences relate to tumor biology. This study aimed to characterize the differences in global transcriptome and pathway activity between CRC tumors of younger and older patients and their relationship to prognosis. Methods: CRC transcriptomes from 15 published studies with at least 3 patients aged < 50 were obtained. The clinical data were compared between the 2 age groups and to the SEER database. Random effects meta-analysis was performed to identify differentially expressed genes (DEGs) in young vs old patients, followed by Gene Set Enrichment Analysis for pathways. An individual “transcriptome age score” was calculated by weighted average expression of DEGs using log fold-change as weights, and then categorized into tertiles (young, mid and old profile). Cox regression for disease-free survival (DFS) were carried out with the transcriptome age score or selected pathways as a predictor, with and without age adjustment. Results: The 15 included studies were comprised of 294 younger and 2517 older patients, who demonstrated clinicopathologic characteristics (Table 1) similar to the SEER database (not shown). Metaanalysis identified 1259 DEGs (FDR < 0.05), which were enriched for upregulated extracellular matrix (ECM) genes,, lysosomal activity, TGF-b and mTOR signaling, pathways related to cancer, as well as downregulated oxidative phosphorylation. Meta-analysis of 5 studies (with DFS data) found tthat the transcriptome age score was significantly associated with DFS (hazard ratio of 1.27 for high vs low tertile independent of age) (Figure 1). Activation of TGF-b signaling, inflammatory responses and EMT as well as downregulation of oxidative phosphorylation and branch chain amino acids degradation (possibly obesity related), were also found to be prognostic, suggesting their roles in carcinogenesis of early onset CRC.Figure 1Table 1: Comparisons of Demographics and Tumor Characteristics between Earlyonset and Late-onset CRCConclusion: Approximately 10% of CRC occur in patients aged < 50. By synthesizing consistent results across multiple studies, we concluded that early onset CRC in general exhibited a unique transcriptome signature that is distinguished from more commonly diagnosed older CRC. Future studies are needed to evaluate preventive and/or therapeutic implications of modulating certain genes/pathways." @default.
• W2978877951 created "2019-10-10" @default.
• W2978877951 creator A5022420344 @default.
• W2978877951 creator A5027664400 @default.
• W2978877951 creator A5052283192 @default.
• W2978877951 creator A5089202777 @default.
• W2978877951 date "2015-10-01" @default.
• W2978877951 modified "2023-09-23" @default.
• W2978877951 title "Global Transcriptome Differences Between Early-Onset and Late-Onset Colorectal Cancer" @default.
• W2978877951 doi "https://doi.org/10.14309/00000434-201510001-01399" @default.
• W2978877951 hasPublicationYear "2015" @default.
• W2978877951 type Work @default.
• W2978877951 sameAs 2978877951 @default.
• W2978877951 citedByCount "0" @default.
• W2978877951 crossrefType "journal-article" @default.
• W2978877951 hasAuthorship W2978877951A5022420344 @default.
• W2978877951 hasAuthorship W2978877951A5027664400 @default.
• W2978877951 hasAuthorship W2978877951A5052283192 @default.
• W2978877951 hasAuthorship W2978877951A5089202777 @default.
• W2978877951 hasConcept C104317684 @default.
• W2978877951 hasConcept C121608353 @default.
• W2978877951 hasConcept C126322002 @default.
• W2978877951 hasConcept C143998085 @default.
• W2978877951 hasConcept C150194340 @default.
• W2978877951 hasConcept C162317418 @default.
• W2978877951 hasConcept C50382708 @default.
• W2978877951 hasConcept C526805850 @default.
• W2978877951 hasConcept C54355233 @default.
• W2978877951 hasConcept C71924100 @default.
• W2978877951 hasConcept C86803240 @default.
• W2978877951 hasConceptScore W2978877951C104317684 @default.
• W2978877951 hasConceptScore W2978877951C121608353 @default.
• W2978877951 hasConceptScore W2978877951C126322002 @default.
• W2978877951 hasConceptScore W2978877951C143998085 @default.
• W2978877951 hasConceptScore W2978877951C150194340 @default.
• W2978877951 hasConceptScore W2978877951C162317418 @default.
• W2978877951 hasConceptScore W2978877951C50382708 @default.
• W2978877951 hasConceptScore W2978877951C526805850 @default.
• W2978877951 hasConceptScore W2978877951C54355233 @default.
• W2978877951 hasConceptScore W2978877951C71924100 @default.
• W2978877951 hasConceptScore W2978877951C86803240 @default.
• W2978877951 hasLocation W29788779511 @default.
• W2978877951 hasOpenAccess W2978877951 @default.
• W2978877951 hasPrimaryLocation W29788779511 @default.
• W2978877951 hasRelatedWork W1971124177 @default.
• W2978877951 hasRelatedWork W2102579905 @default.
• W2978877951 hasRelatedWork W2131160279 @default.
• W2978877951 hasRelatedWork W2513916811 @default.
• W2978877951 hasRelatedWork W2542604898 @default.
• W2978877951 hasRelatedWork W3089353767 @default.
• W2978877951 hasRelatedWork W3097825150 @default.
• W2978877951 hasRelatedWork W3146618441 @default.
• W2978877951 hasRelatedWork W4213265720 @default.
• W2978877951 hasRelatedWork W4247273247 @default.
• W2978877951 hasVolume "110" @default.
• W2978877951 isParatext "false" @default.
• W2978877951 isRetracted "false" @default.
• W2978877951 magId "2978877951" @default.
• W2978877951 workType "article" @default.