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• W2978895327 abstract "Purpose: Menetrier's disease (MenD) is a rare, acquired disorder defined as giant gastric folds in conjunction with a protein-losing enteropathy, hypoor achlorhydria and histologic features of massive foveolar hyperplasia and cystic dilatation. The etiology and epidemiology of this disorder are unknown. AIM: To evaluate the clinical, endoscopic, histologic and radiologic parameters of MenD. Methods: A retrospective investigation of all patients diagnosed with MenD at Mayo Clinic, Rochester between 1975 and 2005. Medical records were reviewed to identify demographics, clinical history, laboratory and imaging parameters, histopathology, additional medical diagnoses, and follow-up course. The diagnosis of MenD was based on a combination of clinical, endoscopic, radiologic and histologic features. Clinical characteristics of MenD were analyzed using descriptive statistics. Results: 80 patients (48 male, age 56 ± 15 years, BMI 24 ± 5 kg/m2) were diagnosed with MenD between 1975 and 2005. The most frequent presenting complaint was abdominal pain (64%) followed by nausea (54%) and weight loss ≥ 10 lbs (54%). Twenty patients (25%) had a pre-existing psychiatric illness prior to the diagnosis of MenD. Twelve patients (15%) had concomitant diabetes mellitus. Four patients (5%) had a pre-existing connective tissue disorder. Nine patients (11%) had either concomitant hypo- or hyperthyroidism. Ulcerative colitis and celiac disease were not commonly found. The mean total protein level at diagnosis was 5.5 ± 1.0 g/dL. The mean albumin level at diagnosis was 3.0 ± 0.7 g/dL. The mean gastrin level at diagnosis was 146 ± 110 pg/mL. Giant gastric folds were found in the body and fundus in 25 patients (33%), gastric body only in 13 (17%), fundus only in 3 (4%), entire stomach in 14 (18%) and gastric antrum only in 3 (4%) patients. Gastric ulcers were found in 4 patients (5%). Sixty-seven patients (84%) had gastric biopsies performed at our institution. The most common histologic finding was massive foveolar hyperplasia (43%). The gastric antrum was involved in 14/45 patients (31%) on radiographic imaging. We identified 7 patients (9%) who developed gastric adenocarcinoma. Conclusion: In our cohort of patients with MenD, the predominant symptoms at presentation were abdominal pain, nausea and weight loss ≥ 10 lbs. MenD has traditionally been associated with antral sparing, although our study showed that 22% had endoscopic evidence of antral involvement. Inflammatory bowel disease and celiac disease were not commonly found in our cohort. As of 2005, we identified 9% of MenD patients who were subsequently diagnosed with gastric adenocarcinoma." @default.
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• W2978895327 date "2012-10-01" @default.
• W2978895327 modified "2023-09-25" @default.
• W2978895327 title "Clinical Profile of Menetrierʼs Disease: A 30-Year Mayo Clinic Experience" @default.
• W2978895327 doi "https://doi.org/10.14309/00000434-201210001-00150" @default.
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