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- W2978895357 abstract "Objective To exam the expression and the distribution of the CDK5 mRNA and protein in the developing rat brain. Methods We used embryonic to aged stage Wistar rats by immunocytochemistry staining with anti-CDK5 antibody as well as in situ hybridization technique. Results 1.There were CDK5 specific mRNA expression in the brain tissue during the period from E14～P350, the stable levels of mRNA were detected at adulthood. The location of the CDK5 mRNA was confined to neuronal cell (but not glial) bodies and their processes. The main distribution of CDK5 mRNA was detected in the regions of the cerebral cortex, hippocampus, thalamus, hypothalamus, cerebellum and some neural nucleus mass. 2. The heavy dense signal of CDK5 protein was found in the brain after born, and the signal decrease at embryonic and aged stage. The immuno-positive cells of newborn and adult stages were observed in periventricular zone, hippocampus, cerebellum and some neural nucleus mass. But at aged stage, CDK5 protein expression were found in the neurons in hippocampus and Purkinje cell in cerebellum, while others were not or weakly stained. Moreover, there were marked decrease of CDK5 protein expression in hippocampus at aged stage compared to adult stage.Conclusion These results suggest that CDK5 involved in the whole neurodevelopmental stages of rat brain. A downregulation of CDK5 may be related to the degeneration of learning and memory at aged stage. [" @default.
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- W2978895357 date "2002-01-01" @default.
- W2978895357 modified "2023-09-25" @default.
- W2978895357 title "Expression and distribution of cyclin-dependent kinase 5 (CDK5) in the developing rat brain" @default.
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