FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978897273> ?p ?o ?g. }

• W2978897273 endingPage "S339" @default.
• W2978897273 startingPage "S339" @default.
• W2978897273 abstract "Introduction: Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare primary malignancy of the liver. There are only case reports of FLHCC occurring in pregnancy. This case report describes management of FLHCC patient to include treatment of FLHCC during pregnancy with yttrium-90 microspheres (Y90). Case Report: 23y/o female at 17 weeks gestation presented for evaluation of upper abdominal pain, elevated liver associated enzymes, and thrombocytopenia found to have multiple intrahepatic lesions and enlarged spleen on ultrasound of the abdomen. Non-contrast MRI revealed multiple hepatic lesions with largest measuring 8.3x10.9cm in the left hepatic lobe with extension into portal vein. EGD revealed grade II esophageal varices and portal hypertensive gastropathy. FNA of hepatic lesions was performed during EUS revealed fibrolamellar hepatocellular carcinoma. Perigastric, splenic, esophageal and pancreatic varices was noted during EUS and patient was placed on beta blocker therapy. Serum AFP was 30. Multidisciplinary tumor meeting held and decision for interventional radiology (IR) consultation for treatment of FLHCC with Y90. Surgery determined patient not a surgical candidate given involvement of hepatic vasculature. Patient received two doses of Y90 to both hepatic lobes during her pregnancy and tolerated without significant issues. Subsequent imaging did not reveal significant change to tumor burden and plan was for possible repeat Y90 nine months after last dose. Management of baby was performed by OB services and was taken to emergent cesarean at 32 weeks gestation of healthy child. Post-delivery patient discussion regarding Sorafenib for treatment of FLHCC however patient declined in order to breast feed which she was did for 3 weeks. Patient agreed to trial with Sorafenib however stopped due to side effects after only doses. Decision was made for patient to move closer to family and her husband was relocated to duty station near family. Discussion: Care of this young patient involved difficult decisions much of which has no formal guidelines. Portal hypertension secondary to large hepatic tumor burden was managed expectantly; however treatment of her FLHCC in the setting of pregnancy with Y90 was a novel approach. Throughout, patient ultimately made decisions to ensure the safety and well-being of her child over her own survivability. Conclusion: FLHCC in pregnancy have no formal guidelines for treatment. Treatment of FLHCC with Y90 during pregnancy can led to viable child delivery and prolonged maternal survival. However, limited data in this setting exist.Figure 1Figure 2Figure 3" @default.
• W2978897273 created "2019-10-10" @default.
• W2978897273 creator A5001731602 @default.
• W2978897273 creator A5020303669 @default.
• W2978897273 creator A5049397902 @default.
• W2978897273 date "2015-10-01" @default.
• W2978897273 modified "2023-09-27" @default.
• W2978897273 title "Y90 Treatment in Pregnant Woman With Fibrolamellar Hepatocellular Carcinoma" @default.
• W2978897273 doi "https://doi.org/10.14309/00000434-201510001-00775" @default.
• W2978897273 hasPublicationYear "2015" @default.
• W2978897273 type Work @default.
• W2978897273 sameAs 2978897273 @default.
• W2978897273 citedByCount "0" @default.
• W2978897273 crossrefType "journal-article" @default.
• W2978897273 hasAuthorship W2978897273A5001731602 @default.
• W2978897273 hasAuthorship W2978897273A5020303669 @default.
• W2978897273 hasAuthorship W2978897273A5049397902 @default.
• W2978897273 hasConcept C126322002 @default.
• W2978897273 hasConcept C126838900 @default.
• W2978897273 hasConcept C2777214474 @default.
• W2978897273 hasConcept C2777595160 @default.
• W2978897273 hasConcept C2778019345 @default.
• W2978897273 hasConcept C2778695046 @default.
• W2978897273 hasConcept C2778808290 @default.
• W2978897273 hasConcept C2779234561 @default.
• W2978897273 hasConcept C2779399171 @default.
• W2978897273 hasConcept C46973012 @default.
• W2978897273 hasConcept C54355233 @default.
• W2978897273 hasConcept C71924100 @default.
• W2978897273 hasConcept C86803240 @default.
• W2978897273 hasConcept C90924648 @default.
• W2978897273 hasConceptScore W2978897273C126322002 @default.
• W2978897273 hasConceptScore W2978897273C126838900 @default.
• W2978897273 hasConceptScore W2978897273C2777214474 @default.
• W2978897273 hasConceptScore W2978897273C2777595160 @default.
• W2978897273 hasConceptScore W2978897273C2778019345 @default.
• W2978897273 hasConceptScore W2978897273C2778695046 @default.
• W2978897273 hasConceptScore W2978897273C2778808290 @default.
• W2978897273 hasConceptScore W2978897273C2779234561 @default.
• W2978897273 hasConceptScore W2978897273C2779399171 @default.
• W2978897273 hasConceptScore W2978897273C46973012 @default.
• W2978897273 hasConceptScore W2978897273C54355233 @default.
• W2978897273 hasConceptScore W2978897273C71924100 @default.
• W2978897273 hasConceptScore W2978897273C86803240 @default.
• W2978897273 hasConceptScore W2978897273C90924648 @default.
• W2978897273 hasLocation W29788972731 @default.
• W2978897273 hasOpenAccess W2978897273 @default.
• W2978897273 hasPrimaryLocation W29788972731 @default.
• W2978897273 hasRelatedWork W2077844404 @default.
• W2978897273 hasRelatedWork W2159651774 @default.
• W2978897273 hasRelatedWork W2164996925 @default.
• W2978897273 hasRelatedWork W2272881959 @default.
• W2978897273 hasRelatedWork W2320218455 @default.
• W2978897273 hasRelatedWork W2395582920 @default.
• W2978897273 hasRelatedWork W2520884834 @default.
• W2978897273 hasRelatedWork W2883703027 @default.
• W2978897273 hasRelatedWork W2902148150 @default.
• W2978897273 hasRelatedWork W3048238215 @default.
• W2978897273 hasVolume "110" @default.
• W2978897273 isParatext "false" @default.
• W2978897273 isRetracted "false" @default.
• W2978897273 magId "2978897273" @default.
• W2978897273 workType "article" @default.