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- W2978923101 abstract "Purpose: After a prescribed course of intravenous proton pump inhibitor therapy, patients may require continued oral antisecretory therapy. The objective of this study was to compare intragastric acid control with oral esomeprazole 40 mg once daily with that of oral pantoprazole 40 mg once daily after 5 days of intravenous pantoprazole 40 mg once daily. Methods: In this randomized, open-label, comparative, 2-way crossover study (D9612L00066), healthy adults were randomized to 1 of 2 dosing sequences. Each 10-day dosing period included 5 days of daily injections over 2 minutes of intravenous pantoprazole followed by 5 days of once-daily oral doses of esomeprazole 40 mg or pantoprazole 40 mg. There was a 10–21-day washout period between dosing periods. All doses were administered, under observation at the investigator's site, 30 minutes before breakfast. Non–high-fat, non–high-calorie meals were provided to study subjects. On days 1 and 5 of oral dosing (before receiving the daily dose), a calibrated electrode was positioned 10 cm below the lower esophageal sphincter for 24-hour pH monitoring. The pH technicians and readers were blinded to subject treatment sequence. Only data from patients who had evaluable tracings from both day-5 tests were included. Results: All 38 subjects with evaluable data were H. pylori-negative and white, 63% were men, and the mean age was 25 years (range, 19 to 57 years). The mean number of evaluable hours of pH data for both treatment groups on both days was 24. Oral esomeprazole was significantly more effective for gastric acid suppression than oral pantoprazole on days 1 and 5 (steady state) of oral dosing (see table) immediately after a course of intravenous pantoprazole. The 16% difference between treatment means on day 5 is equivalent to 3.9 hours of pH > 4 during a 24-hour period.Table: Least-Squares Mean (SEM)% Time of 24 Hours Intragastric pH was >4 on Days 1 and 5 of Oral DosingConclusions: Switching from intravenous pantoprazole to oral esomeprazole 40 mg once daily more effectively suppressed intragastric acid than switching from intravenous pantoprazole to oral pantoprazole 40 mg once daily. Supported by AstraZeneca LP." @default.
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- W2978923101 date "2005-09-01" @default.
- W2978923101 modified "2023-10-16" @default.
- W2978923101 title "Intragastric Acid Control with Oral Esomeprazole or Pantoprazole after Intravenous Pantoprazole Administration in Healthy Adults" @default.
- W2978923101 doi "https://doi.org/10.14309/00000434-200509001-00107" @default.
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