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- W2978923711 abstract "目的利用两亲性嵌段共聚物聚（2-乙基-2-噁唑啉）-聚（D，L-丙交酯）[poly（2-ethyl-2-ox-azoline）-poly（D，L-lacfide），PEOz-PDLLA]的自组装性能制备pH敏感型多西他赛胶束，并对其相关性质进行考察。方法运用阳离子开环聚合反应得到PEOz-PDLLA，通过FITR、^1H-NMR和凝胶色谱法对其结构进行表征，采用电位滴定法测定共聚物pKa，应用荧光探针技术确定临界胶束浓度（critical micelle concentration，CMC）。动态光散射法和Zeta电位测试仪测定胶束的粒径和Zeta电位。以薄膜分散法包载多西他赛，并用透析法研究载药胶柬的体外释放度。结果PEOz-PDLLA的亲水／疏水段分子质量比值为0.76，pKa为6.41，CIVIC为0.8×10^-3g·L^-1。载药胶束包封率为94.9％、载药量质量分数为8.7％、平均粒径为（35.3±4.9）nm、Zeta电位为（25.51±2.14）mV，在pH5.0的释放介质中释药速度加快。结论PEOz-PDLLA嵌段共聚物可自组装形成胶束，高效包载多西他赛，体外释放具有pH敏感性。" @default.
- W2978923711 created "2019-10-10" @default.
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- W2978923711 date "2009-01-01" @default.
- W2978923711 modified "2023-09-24" @default.
- W2978923711 title "多西他赛pH敏感型聚（2-乙基-2-噁唑啉）-聚（D，L-丙交酯）自组装胶束的制备及其性质" @default.
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