Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978952075> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2978952075 abstract "Abstract BACKGROUND: The evaluation of response for brain metastases (BM) may be challenging in the context of treatment by stereotactic radiotherapy (SRT) or immunotherapy or both. METHODS: We reviewed clinical and neuroimaging data of 62 melanoma patients with newly diagnosed BM treated by the combination of immunotherapy and SRT (n=33, group A), immunotherapy alone (n=10, group B) or SRT alone or in combination with other systemic therapies (n=19, group C). Response was assessed using RECIST 1.1, RANO or iRANO criteria. RESULTS: BRAF mutations were noted in 26 patients. 54 patients (87%) had 1–3 metastases. The median DS-GPA was 3. After a median follow-up of 30.5 months, 39 patients have experienced CNS progression, 16 (48.5%) in group A, 9 (90%) in group B, 14 (73.5%) in group C. Median PFS was 129.5 days (range 82–532) in group A, 75 days (range 35–203) in group B, 136 days (range 59–514) in group C. Forty-seven patients (76%) had died at the time of the analysis, 22 (66.5%) in group A, 7 (70%) in group B, 18 (94.5%) in group C. Median OS was 345 days (range 65–1824) in group A, 174.5 days (range 50–1361) in group B, 409 days (range 102–1244) in group C. 52 MRI scans were available for central review: pseudoprogression was documented in 9 patients (29%) in group A, 0 (0%) in group B, 5 (29.5%) in group C. Response rates were similar with all three sets of response criteria. Progressive disease was less often called when applying iRANO to assess SRT target lesions. CONCLUSIONS: Despite the retrospective nature and the small sample size, these data may indicate that the omission of SRT from first-line treatment may compromise outcome. Pseudoprogression is uncommon with immunotherapy alone; pseudoprogression rates were similar after SRT alone or in combination with immunotherapy or other systemic treatment." @default.
- W2978952075 created "2019-10-10" @default.
- W2978952075 creator A5009730024 @default.
- W2978952075 creator A5017177249 @default.
- W2978952075 creator A5051655575 @default.
- W2978952075 creator A5054871359 @default.
- W2978952075 creator A5055289994 @default.
- W2978952075 creator A5064594974 @default.
- W2978952075 creator A5077421764 @default.
- W2978952075 creator A5077744058 @default.
- W2978952075 creator A5089297467 @default.
- W2978952075 date "2019-08-01" @default.
- W2978952075 modified "2023-09-30" @default.
- W2978952075 title "MLTI-13. RESPONSE ASSESSMENT OF MELANOMA BRAIN METASTASES TREATED BY STEREOTACTIC RADIOTHERAPY OR IMMUNOTHERAPY OR BOTH: A COMPARISON OF RECIST 1.1, RANO AND iRANO CRITERIA" @default.
- W2978952075 doi "https://doi.org/10.1093/noajnl/vdz014.072" @default.
- W2978952075 hasPublicationYear "2019" @default.
- W2978952075 type Work @default.
- W2978952075 sameAs 2978952075 @default.
- W2978952075 citedByCount "0" @default.
- W2978952075 crossrefType "journal-article" @default.
- W2978952075 hasAuthorship W2978952075A5009730024 @default.
- W2978952075 hasAuthorship W2978952075A5017177249 @default.
- W2978952075 hasAuthorship W2978952075A5051655575 @default.
- W2978952075 hasAuthorship W2978952075A5054871359 @default.
- W2978952075 hasAuthorship W2978952075A5055289994 @default.
- W2978952075 hasAuthorship W2978952075A5064594974 @default.
- W2978952075 hasAuthorship W2978952075A5077421764 @default.
- W2978952075 hasAuthorship W2978952075A5077744058 @default.
- W2978952075 hasAuthorship W2978952075A5089297467 @default.
- W2978952075 hasBestOaLocation W29789520751 @default.
- W2978952075 hasConcept C121608353 @default.
- W2978952075 hasConcept C126322002 @default.
- W2978952075 hasConcept C126838900 @default.
- W2978952075 hasConcept C16005928 @default.
- W2978952075 hasConcept C19527891 @default.
- W2978952075 hasConcept C2777658100 @default.
- W2978952075 hasConcept C2777701055 @default.
- W2978952075 hasConcept C2780387249 @default.
- W2978952075 hasConcept C2992393070 @default.
- W2978952075 hasConcept C502942594 @default.
- W2978952075 hasConcept C509974204 @default.
- W2978952075 hasConcept C71924100 @default.
- W2978952075 hasConceptScore W2978952075C121608353 @default.
- W2978952075 hasConceptScore W2978952075C126322002 @default.
- W2978952075 hasConceptScore W2978952075C126838900 @default.
- W2978952075 hasConceptScore W2978952075C16005928 @default.
- W2978952075 hasConceptScore W2978952075C19527891 @default.
- W2978952075 hasConceptScore W2978952075C2777658100 @default.
- W2978952075 hasConceptScore W2978952075C2777701055 @default.
- W2978952075 hasConceptScore W2978952075C2780387249 @default.
- W2978952075 hasConceptScore W2978952075C2992393070 @default.
- W2978952075 hasConceptScore W2978952075C502942594 @default.
- W2978952075 hasConceptScore W2978952075C509974204 @default.
- W2978952075 hasConceptScore W2978952075C71924100 @default.
- W2978952075 hasLocation W29789520751 @default.
- W2978952075 hasLocation W29789520752 @default.
- W2978952075 hasOpenAccess W2978952075 @default.
- W2978952075 hasPrimaryLocation W29789520751 @default.
- W2978952075 hasRelatedWork W1968115407 @default.
- W2978952075 hasRelatedWork W2116294833 @default.
- W2978952075 hasRelatedWork W2136507552 @default.
- W2978952075 hasRelatedWork W2563804011 @default.
- W2978952075 hasRelatedWork W2572319409 @default.
- W2978952075 hasRelatedWork W2789510153 @default.
- W2978952075 hasRelatedWork W2947590149 @default.
- W2978952075 hasRelatedWork W2967651920 @default.
- W2978952075 hasRelatedWork W3035446385 @default.
- W2978952075 hasRelatedWork W3047193451 @default.
- W2978952075 hasRelatedWork W3047245025 @default.
- W2978952075 hasRelatedWork W3047504968 @default.
- W2978952075 hasRelatedWork W3048403199 @default.
- W2978952075 hasRelatedWork W3108245780 @default.
- W2978952075 hasRelatedWork W3112521006 @default.
- W2978952075 hasRelatedWork W3128809302 @default.
- W2978952075 hasRelatedWork W3139380336 @default.
- W2978952075 hasRelatedWork W3181961555 @default.
- W2978952075 hasRelatedWork W3184562011 @default.
- W2978952075 hasRelatedWork W3210688856 @default.
- W2978952075 isParatext "false" @default.
- W2978952075 isRetracted "false" @default.
- W2978952075 magId "2978952075" @default.
- W2978952075 workType "article" @default.