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• W2978971141 abstract "Although decreasing in incidence in North America, colorectal carcinoma remains the 3rd most commonly diagnosed cancer in males and 2nd most commonly diagnosed in females. 95% of these cancers are adenocarcinoma. Squamous cell carcinoma of the colorectal region is a rare finding. Many case reports reveal the high prevalence of chronic inflammatory conditions such as ulcerative colitis, HPV and Schistosomiasis infections leading to squamous cell carcinoma. The following case reports an interesting presentation of primary rectal cancer of squamous cells. 93-year old female with past medical history of invasive ductal carcinoma presented to the hospital for diarrhea associated with large amounts of mucus. She was compliant with colonoscopy screenings prior to the age of 75. She had no family history of colorectal cancer in 1st or 2nd degree relatives. She did not smoke or consume alcohol. She led an active lifestyle prior to the acute onset of her symptoms. Leukocytosis of 14,000 was the only abnormal lab finding. HIV, c. difficile PCR and stool cultures were negative. Blood cultures grew s. hominis which was regarded as a contaminant. CT abdomen with oral contrast revealed a 5.1cm posterior rectal mass. This mass circumscribed the rectum, was above the perineum and did not involve the anus, cervix or uterus. The mass did invade the coccyx posteriorly. Colonoscopy revealed a friable mass surrounding the rectal wall which caused partial obstruction. No evidence of any anal involvement could be seen. A rectal stent was placed to provide relief for the patient and biopsy was taken. Surgical biopsy proved to be squamous cell carcinoma and stained positive for p40. Subsequently, p16 tumor suppressor protein also stained positive which indicated HPV infection. Primary squamous cell carcinoma of the rectum is a rare cancer. Unlike anal squamous cell cancers, management and treatment for rectal squamous cancers have not been described. Many case reports described squamous cell rectal cancer to be found at an advanced stage. HPV is associated with 95% of anal and cervical cancers, however the prevalence of HPV infection in rectal carcinoma has not been studied. Since HPV infection is the most common STD in the United States then it could be possible that we would see an increase prevalence of squamous cell cancer of the rectum. The need for screening rectal HPV infection would also need to be adressed if the prevalence of rectal squamous cell cancers increase.Figure 1Figure 2Figure 3" @default.
• W2978971141 created "2019-10-10" @default.
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• W2978971141 date "2016-10-01" @default.
• W2978971141 modified "2023-09-26" @default.
• W2978971141 title "Rectal Carcinoma of Squamous Origin" @default.
• W2978971141 doi "https://doi.org/10.14309/00000434-201610001-01437" @default.
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