FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978973029> ?p ?o ?g. }

• W2978973029 endingPage "S769" @default.
• W2978973029 startingPage "S768" @default.
• W2978973029 abstract "Dermatomyositis (DM) is a rare idiopathic inflammatory muscle and skin disorder with a 2:1 female predominance, and peak incidence in the 5th and 6th decades of life. DM presents acutely or progressively as painless proximal skeletal muscle weakness and can be associated with the characteristic heliotropic rash around the eyes and Gottron's papules on extensor surface of the hands. Individuals may also present with symptoms of dysphagia, and cardiac or pulmonary involvement. We report a 72-year-old female with renal clear cell carcinoma, breast cancer, and papillary serous carcinoma of the uterus, who presented with progressive weakness, 30 pound weight loss, and difficulty swallowing over the past three months. She also reported difficulty ambulating, facial rash, and inability to extend her fingers. Physical examination revealed a cachectic-appearing woman and areas of hyperpigmentation on her face, arms, and legs. She also had symmetric proximal muscle weakness in both upper and lower extremities. Laboratory findings were significant for an elevated serum creatinine phosphokinase level of 3222 U/L, creatine kinase isoform MB 369.7 ng/mL, aldolase 31.7 U/L, erythrocyte sedimentation rate 40 mm/hr, C-reactive protein 8.41 mg/L, lactate dehydrogenase 804 U/L, and antinuclear antibody positive >1:640. Barium esophagram revealed significant difficulty initiating swallow with laryngeal penetration and aspiration of contrast. Esophagogastroduodenoscopy showed pooling of saliva in the piriform fossa with a normal appearing esophagus. A left biceps muscle biopsy revealed inflammatory myositis with significant necrotizing component suggestive of DM. Further staining with nicotinamide adenine dinucleotide tetrazolium reductase (NADH-TR) stain identified frequent myofibers with targetoid-like changes consistent with DM. She was treated with intravenous corticosteroids, however, she did not respond to the treatment. Thus, a percutaneous gastrostomy tube was placed for enteral feeding. DM is an inflammatory myopathy with cutaneous manifestations and associated with malignancy. Striated muscle in the oropharynx and upper one-third of the esophagus are affected, which results in oropharyngeal dysphagia. Patients with muscle weakness and progressive dysphagia can be a hallmark of malignancy. In our patient, DM presented as dysphagia with multiple malignancies with lack of a response to corticosteroid treatment, which portends a poor prognosis.Figure 1Figure 2Figure 3" @default.
• W2978973029 created "2019-10-10" @default.
• W2978973029 creator A5003627821 @default.
• W2978973029 creator A5019120785 @default.
• W2978973029 creator A5028184099 @default.
• W2978973029 creator A5041283318 @default.
• W2978973029 creator A5074891125 @default.
• W2978973029 creator A5087716685 @default.
• W2978973029 creator A5089015604 @default.
• W2978973029 date "2016-10-01" @default.
• W2978973029 modified "2023-10-04" @default.
• W2978973029 title "A Case of Dematomyositis in a Cancer Patient Presenting as Dysphagia" @default.
• W2978973029 doi "https://doi.org/10.14309/00000434-201610001-01630" @default.
• W2978973029 hasPublicationYear "2016" @default.
• W2978973029 type Work @default.
• W2978973029 sameAs 2978973029 @default.
• W2978973029 citedByCount "0" @default.
• W2978973029 crossrefType "journal-article" @default.
• W2978973029 hasAuthorship W2978973029A5003627821 @default.
• W2978973029 hasAuthorship W2978973029A5019120785 @default.
• W2978973029 hasAuthorship W2978973029A5028184099 @default.
• W2978973029 hasAuthorship W2978973029A5041283318 @default.
• W2978973029 hasAuthorship W2978973029A5074891125 @default.
• W2978973029 hasAuthorship W2978973029A5087716685 @default.
• W2978973029 hasAuthorship W2978973029A5089015604 @default.
• W2978973029 hasConcept C126322002 @default.
• W2978973029 hasConcept C142724271 @default.
• W2978973029 hasConcept C2775934546 @default.
• W2978973029 hasConcept C2778570526 @default.
• W2978973029 hasConcept C2778751314 @default.
• W2978973029 hasConcept C2779999465 @default.
• W2978973029 hasConcept C2909745897 @default.
• W2978973029 hasConcept C36880943 @default.
• W2978973029 hasConcept C71924100 @default.
• W2978973029 hasConcept C90924648 @default.
• W2978973029 hasConceptScore W2978973029C126322002 @default.
• W2978973029 hasConceptScore W2978973029C142724271 @default.
• W2978973029 hasConceptScore W2978973029C2775934546 @default.
• W2978973029 hasConceptScore W2978973029C2778570526 @default.
• W2978973029 hasConceptScore W2978973029C2778751314 @default.
• W2978973029 hasConceptScore W2978973029C2779999465 @default.
• W2978973029 hasConceptScore W2978973029C2909745897 @default.
• W2978973029 hasConceptScore W2978973029C36880943 @default.
• W2978973029 hasConceptScore W2978973029C71924100 @default.
• W2978973029 hasConceptScore W2978973029C90924648 @default.
• W2978973029 hasLocation W29789730291 @default.
• W2978973029 hasOpenAccess W2978973029 @default.
• W2978973029 hasPrimaryLocation W29789730291 @default.
• W2978973029 hasRelatedWork W129498665 @default.
• W2978973029 hasRelatedWork W1973327954 @default.
• W2978973029 hasRelatedWork W2000775596 @default.
• W2978973029 hasRelatedWork W2296360751 @default.
• W2978973029 hasRelatedWork W2365939669 @default.
• W2978973029 hasRelatedWork W2379771629 @default.
• W2978973029 hasRelatedWork W2413732983 @default.
• W2978973029 hasRelatedWork W2979800001 @default.
• W2978973029 hasRelatedWork W3004694406 @default.
• W2978973029 hasRelatedWork W3026494681 @default.
• W2978973029 hasVolume "111" @default.
• W2978973029 isParatext "false" @default.
• W2978973029 isRetracted "false" @default.
• W2978973029 magId "2978973029" @default.
• W2978973029 workType "article" @default.