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- W2978974792 abstract "Objective To study the fiseability of treatment of early-stage non-small cell lung cancer(NSCLC) with three dimensional conformal radiation therapy(3D-CRT) combined with chemotherapy for patients who were not suitable for surgery due to medical problems or refused surgery.Methods A total of 60 patients with early were-stage NSCLC diagnosed by pathology or cytology were divided into two groups: 30 patients in the treatment group received chemotherapy(vinorelbine + cisplatin) for 2-4 cycles and 3D-CRT and other 30 patients in the control group received 3D-CRT alone.The method of radiation was same in the two groups,with a total dose of 63-72Gy of radiation at 3-6Gy/fraction,5 fractions/week.Only metastatic lymph nodes and primary tumor were included in the gross target volume.Results The 1-,2-,and 3-year survival rates of the treatment and control groups were 100%,90.5%,81.2% and 100%,78.6%,56.5%,respectively.The survival rates of the treatment group were higher than those of the control group,but the difference had no statistical significance(P0.05).The incidence rate of myelosuppression in the treatment and control groups were 100% vs 20% respectively,the difference had statistical significance(P0.05).None of 60 patients developed grade 3 or worse pulmonary and esophageal toxicity.Conclusion Efficacy of 3D-CRT alone for early-stage inoperable NSCLC was similar to that of surgery.3D-CRT combined with chemotherapy could improve survival rate by reducing the rate of distant metatasis,and the toxicity was tolerable.It is valuable to investigate more deeply." @default.
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- W2978974792 date "2009-01-01" @default.
- W2978974792 modified "2023-09-26" @default.
- W2978974792 title "Clinical observation of the three dimensional conformal radiation therapy(3D-CRT) combined with chemotherapy for treatment of early-stage non-small cell lung cancer" @default.
- W2978974792 hasPublicationYear "2009" @default.
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