FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2978978074> ?p ?o ?g. }

• W2978978074 endingPage "156" @default.
• W2978978074 startingPage "146" @default.
• W2978978074 abstract "In order to establish whether the antioxidant and iron-chelating activities of R-apomorphine (R-APO), a D1-D2 receptor agonist, may contribute to its neuroprotective property, its S-isomer, which is not a dopamine agonist, was studied. The neuroprotective property of R- and S-APO has been studied in the MPTP model of Parkinson's disease (PD). Both S-APO (0.5–1 mg/kg, subcutaneous) and R-APO (10 mg/kg) pretreatment of C57-BL mice, protected against MPTP (24 mg/kg, intraperitoneally) induced dopamine (DA) depletion and reduction in tyrosine hydroxylase (TH) activity. However, only R-APO prevented nigro-striatal neuronal cell degeneration, as indicated by the immunohistochemistry of TH positive neurones in substantia nigra and by western analysis of striatal TH content. R-APO prevented the reduction of striatal-GSH and the increase in the ratio of GSSG over total glutathione, caused by MPTP treatment. In vitro both R-APO and S-APO inhibited monoamine oxidase A and B activity at relatively high concentrations (100 and 300 µmol/L, respectively). The elevated activity of TH induced by the two enantiomers may contribute to the maintenance of normal DA levels, suggesting that one of the targets of these molecules may involve upregulation of TH activity. It is suggested that the antioxidant and iron-chelating properties, possible monoamine oxidase inhibitory actions, together with activation of DA receptors, may participate in the mechanism of neuroprotection by APO enantiomers against MPTP." @default.
• W2978978074 created "2019-10-10" @default.
• W2978978074 creator A5026615241 @default.
• W2978978074 creator A5053858269 @default.
• W2978978074 creator A5068384459 @default.
• W2978978074 creator A5074585037 @default.
• W2978978074 date "2008-06-28" @default.
• W2978978074 modified "2023-10-17" @default.
• W2978978074 title "Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss" @default.
• W2978978074 cites W1501428936 @default.
• W2978978074 cites W1512211793 @default.
• W2978978074 cites W1820596764 @default.
• W2978978074 cites W1963655669 @default.
• W2978978074 cites W1963932280 @default.
• W2978978074 cites W1966918485 @default.
• W2978978074 cites W1969314995 @default.
• W2978978074 cites W1974018971 @default.
• W2978978074 cites W1979907905 @default.
• W2978978074 cites W1982263172 @default.
• W2978978074 cites W1989277130 @default.
• W2978978074 cites W1989708681 @default.
• W2978978074 cites W1997024999 @default.
• W2978978074 cites W2003579541 @default.
• W2978978074 cites W2004611188 @default.
• W2978978074 cites W2005102504 @default.
• W2978978074 cites W2006283117 @default.
• W2978978074 cites W2015723254 @default.
• W2978978074 cites W2016336099 @default.
• W2978978074 cites W2018154493 @default.
• W2978978074 cites W2019983337 @default.
• W2978978074 cites W2031608870 @default.
• W2978978074 cites W2031761772 @default.
• W2978978074 cites W2035386076 @default.
• W2978978074 cites W2039929887 @default.
• W2978978074 cites W2041480702 @default.
• W2978978074 cites W2048041654 @default.
• W2978978074 cites W2049733399 @default.
• W2978978074 cites W2049800884 @default.
• W2978978074 cites W2051347660 @default.
• W2978978074 cites W2061209445 @default.
• W2978978074 cites W2061618733 @default.
• W2978978074 cites W2063707367 @default.
• W2978978074 cites W2065700794 @default.
• W2978978074 cites W2066721457 @default.
• W2978978074 cites W2066908355 @default.
• W2978978074 cites W2070546959 @default.
• W2978978074 cites W2071164093 @default.
• W2978978074 cites W2078376971 @default.
• W2978978074 cites W2079307348 @default.
• W2978978074 cites W2079806597 @default.
• W2978978074 cites W2080194915 @default.
• W2978978074 cites W2083065734 @default.
• W2978978074 cites W2086347584 @default.
• W2978978074 cites W2092089024 @default.
• W2978978074 cites W2095378987 @default.
• W2978978074 cites W2098585148 @default.
• W2978978074 cites W2125211730 @default.
• W2978978074 cites W2130696280 @default.
• W2978978074 cites W2146291656 @default.
• W2978978074 cites W2151631627 @default.
• W2978978074 cites W2165108417 @default.
• W2978978074 cites W2170581022 @default.
• W2978978074 cites W2171047055 @default.
• W2978978074 cites W2279398711 @default.
• W2978978074 cites W4293247451 @default.
• W2978978074 doi "https://doi.org/10.1046/j.1471-4159.2001.00227.x" @default.
• W2978978074 hasPublicationYear "2008" @default.
• W2978978074 type Work @default.
• W2978978074 sameAs 2978978074 @default.
• W2978978074 citedByCount "10" @default.
• W2978978074 countsByYear W29789780742012 @default.
• W2978978074 countsByYear W29789780742020 @default.
• W2978978074 crossrefType "journal-article" @default.
• W2978978074 hasAuthorship W2978978074A5026615241 @default.
• W2978978074 hasAuthorship W2978978074A5053858269 @default.
• W2978978074 hasAuthorship W2978978074A5068384459 @default.
• W2978978074 hasAuthorship W2978978074A5074585037 @default.
• W2978978074 hasConcept C126322002 @default.
• W2978978074 hasConcept C134018914 @default.
• W2978978074 hasConcept C137183658 @default.
• W2978978074 hasConcept C159167319 @default.
• W2978978074 hasConcept C170493617 @default.
• W2978978074 hasConcept C181199279 @default.
• W2978978074 hasConcept C185592680 @default.
• W2978978074 hasConcept C25498285 @default.
• W2978978074 hasConcept C2776024655 @default.
• W2978978074 hasConcept C2777525119 @default.
• W2978978074 hasConcept C2778674702 @default.
• W2978978074 hasConcept C2778938600 @default.
• W2978978074 hasConcept C2780938664 @default.
• W2978978074 hasConcept C39398028 @default.
• W2978978074 hasConcept C513476851 @default.
• W2978978074 hasConcept C55493867 @default.
• W2978978074 hasConcept C71924100 @default.
• W2978978074 hasConcept C86803240 @default.
• W2978978074 hasConcept C98274493 @default.
• W2978978074 hasConceptScore W2978978074C126322002 @default.
• W2978978074 hasConceptScore W2978978074C134018914 @default.

• next