FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979028045> ?p ?o ?g. }

• W2979028045 endingPage "144" @default.
• W2979028045 startingPage "133" @default.
• W2979028045 abstract "Abstract Kawasaki disease (KD) is an acute systemic vasculitis and activation of monocytes plays a central role in the pathogenesis of it. B10 cells, a B cell subset with negative regulatory properties, are functionally identified by their ability to express cytoplasmic IL-10 after ex vivo stimulation. Here, we aimed to explore the functional role of B10 cells during monocyte-mediated inflammatory responses in KD, as well as elucidate the underlying microRNA (miRNA)-mediated regulatory mechanisms. Expression of IL-10 by each group of B cells (total B cells, transitional B cells, naïve B cells, and memory B cells) and inhibition of monocyte-derived TNF-α by activated B cells were measured by flow cytometry. Expression of miRNAs (miR-21-3p, miR-98-5p/3p, miR-27a-3p, let7b-5p, and miR-1423p/5p) that affect IL-10 levels in B cells was quantitated by real-time PCR. The relationship between IL-10 and these miRNAs was examined by multivariate analysis. MiR-mediated RNA interference in B cells was performed to investigate the role of miR-27a on expression of IL-10. The results showed expression of cytoplasmic IL-10 in B cell subsets from patients with KD was down-regulated. The inhibitory effect of B10 cells on production of TNF-α by monocytes from patients with KD was also compromised. The miR-27a-3p expression was markedly up-regulated during the acute phrase of KD, and it promoted monocyte-mediated TNF-α release by negatively regulating expression of cytoplasmic IL-10 within B cells in vitro. The data suggest up-regulated miR-27a in B cells from patients with KD may promote monocyte-mediated inflammatory responses by inhibiting the regulatory function of B10 cells." @default.
• W2979028045 created "2019-10-10" @default.
• W2979028045 creator A5001871643 @default.
• W2979028045 creator A5005347084 @default.
• W2979028045 creator A5011075044 @default.
• W2979028045 creator A5020728310 @default.
• W2979028045 creator A5025701096 @default.
• W2979028045 creator A5026174513 @default.
• W2979028045 creator A5057538695 @default.
• W2979028045 creator A5058999472 @default.
• W2979028045 creator A5064164363 @default.
• W2979028045 creator A5068868633 @default.
• W2979028045 creator A5075124334 @default.
• W2979028045 creator A5089124196 @default.
• W2979028045 date "2019-10-03" @default.
• W2979028045 modified "2023-10-16" @default.
• W2979028045 title "Up-regulation of miR-27a promotes monocyte-mediated inflammatory responses in Kawasaki disease by inhibiting function of B10 cells" @default.
• W2979028045 cites W1486524729 @default.
• W2979028045 cites W1511765608 @default.
• W2979028045 cites W1583260797 @default.
• W2979028045 cites W1648818405 @default.
• W2979028045 cites W1983626608 @default.
• W2979028045 cites W1987201955 @default.
• W2979028045 cites W1989101554 @default.
• W2979028045 cites W2006236831 @default.
• W2979028045 cites W2011497626 @default.
• W2979028045 cites W2015106927 @default.
• W2979028045 cites W2016105256 @default.
• W2979028045 cites W2017549908 @default.
• W2979028045 cites W2025922722 @default.
• W2979028045 cites W2053452881 @default.
• W2979028045 cites W2066585969 @default.
• W2979028045 cites W2099443640 @default.
• W2979028045 cites W2099785704 @default.
• W2979028045 cites W2103573355 @default.
• W2979028045 cites W2109307899 @default.
• W2979028045 cites W2125945390 @default.
• W2979028045 cites W2134939208 @default.
• W2979028045 cites W2140266448 @default.
• W2979028045 cites W2158431089 @default.
• W2979028045 cites W2163716193 @default.
• W2979028045 cites W2165025975 @default.
• W2979028045 cites W2165104559 @default.
• W2979028045 cites W2192190172 @default.
• W2979028045 cites W2214005756 @default.
• W2979028045 cites W2463895832 @default.
• W2979028045 cites W2513387897 @default.
• W2979028045 cites W2604027935 @default.
• W2979028045 cites W2610702412 @default.
• W2979028045 cites W2775072525 @default.
• W2979028045 cites W2784247690 @default.
• W2979028045 cites W2793400884 @default.
• W2979028045 cites W2897707650 @default.
• W2979028045 cites W2903915535 @default.
• W2979028045 cites W2911027444 @default.
• W2979028045 cites W2914878384 @default.
• W2979028045 doi "https://doi.org/10.1002/jlb.5a0919-075rr" @default.
• W2979028045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31583766" @default.
• W2979028045 hasPublicationYear "2019" @default.
• W2979028045 type Work @default.
• W2979028045 sameAs 2979028045 @default.
• W2979028045 citedByCount "14" @default.
• W2979028045 countsByYear W29790280452020 @default.
• W2979028045 countsByYear W29790280452021 @default.
• W2979028045 countsByYear W29790280452022 @default.
• W2979028045 countsByYear W29790280452023 @default.
• W2979028045 crossrefType "journal-article" @default.
• W2979028045 hasAuthorship W2979028045A5001871643 @default.
• W2979028045 hasAuthorship W2979028045A5005347084 @default.
• W2979028045 hasAuthorship W2979028045A5011075044 @default.
• W2979028045 hasAuthorship W2979028045A5020728310 @default.
• W2979028045 hasAuthorship W2979028045A5025701096 @default.
• W2979028045 hasAuthorship W2979028045A5026174513 @default.
• W2979028045 hasAuthorship W2979028045A5057538695 @default.
• W2979028045 hasAuthorship W2979028045A5058999472 @default.
• W2979028045 hasAuthorship W2979028045A5064164363 @default.
• W2979028045 hasAuthorship W2979028045A5068868633 @default.
• W2979028045 hasAuthorship W2979028045A5075124334 @default.
• W2979028045 hasAuthorship W2979028045A5089124196 @default.
• W2979028045 hasConcept C104317684 @default.
• W2979028045 hasConcept C145059251 @default.
• W2979028045 hasConcept C153911025 @default.
• W2979028045 hasConcept C159654299 @default.
• W2979028045 hasConcept C17991360 @default.
• W2979028045 hasConcept C203014093 @default.
• W2979028045 hasConcept C2778453870 @default.
• W2979028045 hasConcept C2781184567 @default.
• W2979028045 hasConcept C553184892 @default.
• W2979028045 hasConcept C55493867 @default.
• W2979028045 hasConcept C86803240 @default.
• W2979028045 hasConcept C95444343 @default.
• W2979028045 hasConceptScore W2979028045C104317684 @default.
• W2979028045 hasConceptScore W2979028045C145059251 @default.
• W2979028045 hasConceptScore W2979028045C153911025 @default.
• W2979028045 hasConceptScore W2979028045C159654299 @default.
• W2979028045 hasConceptScore W2979028045C17991360 @default.
• W2979028045 hasConceptScore W2979028045C203014093 @default.
• W2979028045 hasConceptScore W2979028045C2778453870 @default.

• next