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• W2979031831 abstract "Introduction: Vitamin D deficiency is linked to several gastrointestinal malignancies including gastric cancer and affects a multitude of cellular processes involved in tumorigenesis. Vitamin D is presumed to have anticancer actions by inducing differentiation and cell cycle arrest in malignant cells. Furthermore, it significantly promotes apoptosis in the undifferentiated gastric cancer cell line HGC-27. The aim of this study was to determine whether there is an increased risk of gastric adenocarcinoma (GA) associated with vitamin d deficiency. Methods: A retrospective case-control study was conducted at Elmhurst Hospital Center from 2005-2015. Three hundred and four patients who were diagnosed with GA were selected as cases. Of 304 individuals with GA, 255 were excluded, because they did not have vitamin D levels, 49 patients were included in our study. The data was compared to a matched control group of 49 patients with no known malignancies who had vitamin D levels. Prevalence of vitamin D deficiency was compared between cases and controls using odds ratios (ORs) and 95% confidence intervals. Results: The mean age of the case sample was 63.96 vs 60.43% in the control group. The gender distribution was the same, 49% male and 51% female. Hispanic patients were predominant in both samples accounting for 61.2% of the groups (Table 1). Of 49 patients with GA included in our study, 20.48% were stage I; 36.7% were stage II; 24.9% were stage III, and 18.4% were stage IV. The prevalence of vitamin D deficiency in the case group (GA) was significantly higher than in the control group 19[38.8%] vs 7[14.3%] respectively (OR: 3.8, 95% CI 1.42-10.18, P value 0.0079) (Figure 1).Figure 1Table 1: Baseline Characteristics of the PatientsConclusion: The results of our study suggest that there is a positive correlation between vitamin D deficiency and gastric adenocarcinoma. More specifically patients with vitamin D deficiency have an increased association with gastric adenocarcinoma. Additional multicenter randomized double blind clinical trials are required to further assess this association and the potential benefit of vitamin D supplementation in preventing gastric adenocarcinoma." @default.
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• W2979031831 date "2015-10-01" @default.
• W2979031831 modified "2023-09-27" @default.
• W2979031831 title "Association Between Vitamin D and Gastric Cancer" @default.
• W2979031831 doi "https://doi.org/10.14309/00000434-201510001-02501" @default.
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