Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979073321> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2979073321 endingPage "S153" @default.
- W2979073321 startingPage "S153" @default.
- W2979073321 abstract "Autoimmune enteropathy was initially described as erosive jejuno-ileitis and has subsequently occured predominately in children. This patient demonstrates the efficacy of tacrolimus (FK506) in an adult with autoimmune enteropathy. This 64 year old male, presented with a 50 lb of weight loss over 3 months and severe diarrhea without abdominal pain. Endoscopy revealed diffuse erosions of the small bowel mucosa with colonic sparing. Labs demonstrated macrocytic anemia and hypoalbuminemia. There were no obvious nutritient deficiencies. Stool samples were consistently found to be secretory and occult blood positive. He was not responsive to a strict gluten free diet and high dose oral steroids. Continued weight loss and severe diarrhea led to hospital-ization, high dose intravenous steroids and TPN. The initial histopathologic analysis consisted of a duodenal biopsy with marked villous blunting and focal active duodenitis. Of note, there was no intraepithelial lymphocyto-sis. Colonic, gastric and esophageal biopy specimens were unremarkable. Full thickness biopsies of the jejunum and ileum showed changes similar to the initial duodenal specimen. The inflammatory changes were diffuse in nature and limited to the mucosa. There was no evidence of submucosal inflammation, granulomata, infection, fibrosis or malignancy. An extensive immunohistochemical work-up proved that the mucosal infiltrate was poly-clonal. The patient was discharged home on TPN and high dose intravenous steroids, with decreased diarrhea, but without effect on malabsorption, malnutrition, and mucosal histology. A trial of tacrolimus (FK506) was initiated, based on the use of tacrolimus in autoimmune enteropathy in children. Tacrolimus doses were adjusted to maintain a therapeutic serum level (trough of 7–10 ng/mL). Within 6 months steroids were completely withdrawn without recurrence of diarrhea. The patient has regained 25 lb of lean body mass. Tacrolimus (FK506) can be an effective treatment of autoimmune enteropathy in adults." @default.
- W2979073321 created "2019-10-10" @default.
- W2979073321 creator A5023880351 @default.
- W2979073321 creator A5038263447 @default.
- W2979073321 creator A5050796054 @default.
- W2979073321 date "2004-10-01" @default.
- W2979073321 modified "2023-10-17" @default.
- W2979073321 title "TREATMENT OF ADULT ONSET AUTOIMMUNE ENTEROPATHY WITH TACROLIMUS (FK506)" @default.
- W2979073321 doi "https://doi.org/10.14309/00000434-200410001-00467" @default.
- W2979073321 hasPublicationYear "2004" @default.
- W2979073321 type Work @default.
- W2979073321 sameAs 2979073321 @default.
- W2979073321 citedByCount "0" @default.
- W2979073321 crossrefType "journal-article" @default.
- W2979073321 hasAuthorship W2979073321A5023880351 @default.
- W2979073321 hasAuthorship W2979073321A5038263447 @default.
- W2979073321 hasAuthorship W2979073321A5050796054 @default.
- W2979073321 hasConcept C126322002 @default.
- W2979073321 hasConcept C142724271 @default.
- W2979073321 hasConcept C181152851 @default.
- W2979073321 hasConcept C2775934546 @default.
- W2979073321 hasConcept C2776009029 @default.
- W2979073321 hasConcept C2776140321 @default.
- W2979073321 hasConcept C2778426112 @default.
- W2979073321 hasConcept C2779134260 @default.
- W2979073321 hasConcept C2779280984 @default.
- W2979073321 hasConcept C2779802037 @default.
- W2979073321 hasConcept C2780439177 @default.
- W2979073321 hasConcept C2780941987 @default.
- W2979073321 hasConcept C2909675724 @default.
- W2979073321 hasConcept C2911091166 @default.
- W2979073321 hasConcept C71924100 @default.
- W2979073321 hasConcept C90924648 @default.
- W2979073321 hasConceptScore W2979073321C126322002 @default.
- W2979073321 hasConceptScore W2979073321C142724271 @default.
- W2979073321 hasConceptScore W2979073321C181152851 @default.
- W2979073321 hasConceptScore W2979073321C2775934546 @default.
- W2979073321 hasConceptScore W2979073321C2776009029 @default.
- W2979073321 hasConceptScore W2979073321C2776140321 @default.
- W2979073321 hasConceptScore W2979073321C2778426112 @default.
- W2979073321 hasConceptScore W2979073321C2779134260 @default.
- W2979073321 hasConceptScore W2979073321C2779280984 @default.
- W2979073321 hasConceptScore W2979073321C2779802037 @default.
- W2979073321 hasConceptScore W2979073321C2780439177 @default.
- W2979073321 hasConceptScore W2979073321C2780941987 @default.
- W2979073321 hasConceptScore W2979073321C2909675724 @default.
- W2979073321 hasConceptScore W2979073321C2911091166 @default.
- W2979073321 hasConceptScore W2979073321C71924100 @default.
- W2979073321 hasConceptScore W2979073321C90924648 @default.
- W2979073321 hasLocation W29790733211 @default.
- W2979073321 hasOpenAccess W2979073321 @default.
- W2979073321 hasPrimaryLocation W29790733211 @default.
- W2979073321 hasRelatedWork W1963777964 @default.
- W2979073321 hasRelatedWork W2001133803 @default.
- W2979073321 hasRelatedWork W2003054397 @default.
- W2979073321 hasRelatedWork W2015400436 @default.
- W2979073321 hasRelatedWork W2027528481 @default.
- W2979073321 hasRelatedWork W2032519173 @default.
- W2979073321 hasRelatedWork W2138628469 @default.
- W2979073321 hasRelatedWork W2240157579 @default.
- W2979073321 hasRelatedWork W2396045823 @default.
- W2979073321 hasRelatedWork W2404574058 @default.
- W2979073321 hasVolume "99" @default.
- W2979073321 isParatext "false" @default.
- W2979073321 isRetracted "false" @default.
- W2979073321 magId "2979073321" @default.
- W2979073321 workType "article" @default.