FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979074683> ?p ?o ?g. }

• W2979074683 abstract "Abstract The gut microbiota plays a crucial role in regulating and maintaining the epithelial barrier, particularly during early life. Notably, patients with chronic intestinal inflammation have a dysregulated process of renewal and replenishment of the intestinal epithelial cell (IEC) barrier, which is linked to disturbances in the gut microbiota. To date, there are no studies focussed on understanding the impact of inflammatory cell shedding events during the early life developmental window, and which host and microbial factors mediate these responses. Here we sought to determine pathological cell shedding outcomes throughout the postnatal developmental period (day 14, 21, 29 and week 8). Surprisingly neonatal mice (day 14 and 21) were highly refractory to induction of cell shedding after intraperitoneal administration of LPS, with day 29 mice showing strong pathological responses, more similar to those observed in adult mice. These differential responses were not linked to defects in the cellular mechanisms and pathways known to regulate cell shedding responses, although we did observe that neonatal mice had elevated anti-inflammatory (IL-10) responses. Notably, when we profiled microbiota and metabolites from these mice, we observed significant alterations. Neonatal mice had high relative abundances of Streptococcus , Escherichia and Enterococcus and increased primary bile acids. In contrast, older mice were dominated by Candidatus Arthromitus, Alistipes and Lachnoclostridium , and had increased concentrations of SCFAs and methyamines. Faecal microbiota transplant (FMT) and antibiotic studies confirmed the importance of early life gut microbiota in cell shedding responses. In these studies, neonates treated with antibiotics restored LPS-induced small intestinal cell shedding, whereas adult FMT alone had no effect. Our findings further support the importance of the early life window for microbiota-epithelial interactions in the presence of inflammatory stimuli and highlight areas for further investigation to probe underlying mechanisms to drive therapeutic development within the context of chronic inflammatory intestinal diseases." @default.
• W2979074683 created "2019-10-10" @default.
• W2979074683 creator A5029830005 @default.
• W2979074683 creator A5039246697 @default.
• W2979074683 creator A5040133703 @default.
• W2979074683 creator A5046594988 @default.
• W2979074683 creator A5046720174 @default.
• W2979074683 creator A5048928273 @default.
• W2979074683 creator A5051552996 @default.
• W2979074683 creator A5062426113 @default.
• W2979074683 creator A5063471667 @default.
• W2979074683 creator A5088021192 @default.
• W2979074683 date "2019-10-01" @default.
• W2979074683 modified "2023-10-16" @default.
• W2979074683 title "The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding" @default.
• W2979074683 cites W1992325707 @default.
• W2979074683 cites W2026469847 @default.
• W2979074683 cites W2050669247 @default.
• W2979074683 cites W2056199674 @default.
• W2979074683 cites W2060839471 @default.
• W2979074683 cites W2099471877 @default.
• W2979074683 cites W2105480441 @default.
• W2979074683 cites W2108244474 @default.
• W2979074683 cites W2126592942 @default.
• W2979074683 cites W2148459495 @default.
• W2979074683 cites W2149314119 @default.
• W2979074683 cites W2159861680 @default.
• W2979074683 cites W2164866097 @default.
• W2979074683 cites W2339478720 @default.
• W2979074683 cites W2581494425 @default.
• W2979074683 cites W2599036809 @default.
• W2979074683 cites W2620042743 @default.
• W2979074683 cites W2621592178 @default.
• W2979074683 cites W2732858253 @default.
• W2979074683 cites W2733095074 @default.
• W2979074683 cites W2770311021 @default.
• W2979074683 cites W2773688382 @default.
• W2979074683 cites W2774547239 @default.
• W2979074683 cites W2782401411 @default.
• W2979074683 cites W2802827720 @default.
• W2979074683 cites W2806527086 @default.
• W2979074683 cites W2845130796 @default.
• W2979074683 cites W2885093728 @default.
• W2979074683 cites W2886322630 @default.
• W2979074683 cites W2888407064 @default.
• W2979074683 cites W2896481903 @default.
• W2979074683 cites W2896775536 @default.
• W2979074683 cites W2898147830 @default.
• W2979074683 cites W2899391538 @default.
• W2979074683 cites W2911721984 @default.
• W2979074683 cites W2913097383 @default.
• W2979074683 cites W2930201834 @default.
• W2979074683 cites W2939821466 @default.
• W2979074683 cites W2970428830 @default.
• W2979074683 cites W2973821866 @default.
• W2979074683 doi "https://doi.org/10.1101/789362" @default.
• W2979074683 hasPublicationYear "2019" @default.
• W2979074683 type Work @default.
• W2979074683 sameAs 2979074683 @default.
• W2979074683 citedByCount "0" @default.
• W2979074683 crossrefType "posted-content" @default.
• W2979074683 hasAuthorship W2979074683A5029830005 @default.
• W2979074683 hasAuthorship W2979074683A5039246697 @default.
• W2979074683 hasAuthorship W2979074683A5040133703 @default.
• W2979074683 hasAuthorship W2979074683A5046594988 @default.
• W2979074683 hasAuthorship W2979074683A5046720174 @default.
• W2979074683 hasAuthorship W2979074683A5048928273 @default.
• W2979074683 hasAuthorship W2979074683A5051552996 @default.
• W2979074683 hasAuthorship W2979074683A5062426113 @default.
• W2979074683 hasAuthorship W2979074683A5063471667 @default.
• W2979074683 hasAuthorship W2979074683A5088021192 @default.
• W2979074683 hasBestOaLocation W29790746831 @default.
• W2979074683 hasConcept C12914427 @default.
• W2979074683 hasConcept C134018914 @default.
• W2979074683 hasConcept C143121216 @default.
• W2979074683 hasConcept C203014093 @default.
• W2979074683 hasConcept C2522874641 @default.
• W2979074683 hasConcept C2776145723 @default.
• W2979074683 hasConcept C2776914184 @default.
• W2979074683 hasConcept C2777882243 @default.
• W2979074683 hasConcept C2781077229 @default.
• W2979074683 hasConcept C529295009 @default.
• W2979074683 hasConcept C539455810 @default.
• W2979074683 hasConcept C54355233 @default.
• W2979074683 hasConcept C60644358 @default.
• W2979074683 hasConcept C86803240 @default.
• W2979074683 hasConcept C89423630 @default.
• W2979074683 hasConceptScore W2979074683C12914427 @default.
• W2979074683 hasConceptScore W2979074683C134018914 @default.
• W2979074683 hasConceptScore W2979074683C143121216 @default.
• W2979074683 hasConceptScore W2979074683C203014093 @default.
• W2979074683 hasConceptScore W2979074683C2522874641 @default.
• W2979074683 hasConceptScore W2979074683C2776145723 @default.
• W2979074683 hasConceptScore W2979074683C2776914184 @default.
• W2979074683 hasConceptScore W2979074683C2777882243 @default.
• W2979074683 hasConceptScore W2979074683C2781077229 @default.
• W2979074683 hasConceptScore W2979074683C529295009 @default.
• W2979074683 hasConceptScore W2979074683C539455810 @default.
• W2979074683 hasConceptScore W2979074683C54355233 @default.
• W2979074683 hasConceptScore W2979074683C60644358 @default.

• next