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- W2979103618 abstract "Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare pulmonary vascular disease for which epidemiological data are limited and no ICD-10 diagnosis code was available in the French national hospital discharge database (PMSI). The objective was to develop and validate an algorithm identifying patients with CTEPH within the PMSI, and to estimate the number of patients hospitalized for CTEPH in France in 2015. An expert committee designed a first algorithm combining diagnoses and procedures codes, based on their CTEPH care pathway knowledge, published algorithms and analysis of coding of confirmed CTEPH cases in the PMSI. Then, the algorithm underwent a stepwise refinement, based on matched data from PMSI and patient records with clinically validated CTEPH diagnosis, provided by a first participating expert centre (Paris). Lastly, performance indicators of the final algorithm were measured using patient records from the second participating expert centre (Lyon). The selected algorithm consisted of ≥1 secondary pulmonary hypertension (PH) diagnosis over 2015 and any of the following criteria over a previous 6-year period: (i) CTEPH-specific interventional procedure, (ii) admission for PH and pulmonary embolism (PE), (iii) PE followed by hospitalization in competence centre then in reference centre, (iv) history of PE and right heart catheterization. Patients with conditions suggestive of pulmonary arterial hypertension were excluded. The final algorithm had 95% specificity, 70% sensitivity, 99% negative predictive value, and 41% positive predictive value. When applied to all PMSI and after correction based on algorithm performance, 3,138 patients hospitalized for CTEPH were estimated in 2015 (47 cases/million). This first algorithm allowing the identification of CTEPH cases into the PMSI database provides an estimate of the prevalence of CTEPH in France, notably useful for budget impact evaluations." @default.
- W2979103618 created "2019-10-10" @default.
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- W2979103618 date "2018-10-01" @default.
- W2979103618 modified "2023-09-27" @default.
- W2979103618 title "PRS12 - DEVELOPMENT AND VALIDATION OF AN ALGORITHM IDENTIFYING CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION (CTEPH) IN HOSPITAL DISCHARGE DATABASES" @default.
- W2979103618 doi "https://doi.org/10.1016/j.jval.2018.09.2406" @default.
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