FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979152034> ?p ?o ?g. }

• W2979152034 endingPage "S177" @default.
• W2979152034 startingPage "S176" @default.
• W2979152034 abstract "Granulomatosis with Polyangiitis (GPA), is an ANCA-positive vasculitis that affects the small and medium size vessels of various organs, including those of respiratory tract, lungs, and the kidneys. Gastrointestinal manifestation of GPA is rare, with an estimated prevalence of 5 to 11%. Furthermore, severe gastrointestinal involvement such as bowel perforation or hemorrhage, are even rarer manifestations of GPA. Although the use steroids and cyclophosphamide has become the standard of practice for treating GPA, there is insufficient evidence on the treatment of patients with severe gastrointestinal involvement. We report a case of a 50 year old previously healthy man who presented to our hospital with a 3 month history of migratory polyarthritis and new onset abdominal pain, bloody diarrhea, and oral ulcers after returning from a trip to French Polynesia. Based on laboratory, serologic, radiographic (Figure 1), and endoscopic findings (Figure 2), he was diagnosed with GPA. Soon after the diagnosis, he suffered a colonic perforation, requiring an exploratory laparotomy (Figure 3). He was treated with Prednisone and Rituximab, which proved to be effective therapies in inducing and maintaining clinical remission. The patient currently remains 6 months out from his hospitalization, and has maintained clinical remission on rituximab and a steroid taper. He has continued to do well with no clinical evidence of disease activity, and normalization of his laboratory markers.Figure 1Figure 2Figure 3Prompt diagnosis of GPA is important, as expeditious initiation of therapy is often necessary to reduce mortality and morbidity of multiorgan involvement. Gastrointestinal involvement is an uncommon presentation of GPA. Although local necrotizing arteriolitis of the intestine has been seen in 24% of GPA cases at autopsy, clinically apparent gastrointestinal manifestations of GPA have been reported only at a rate of 5-11%. Moreover, early intestinal perforation or rectal bleeding are even rarer manifestations of the disease, and have only been reported in a small number of cases. Given its rarity, there is limited data concerning the management of severe intestinal involvement in GPA. There have been series of reports that have shown successful use of Rituximab in patients with intestinal perforation secondary to GPA. In our patient's case, early Rituximab therapy in combination with high dose steroids proved to be a safe and effective treatment of his severe gastrointestinal involvement. In conclusion, the presented case report illustrates that severe complications such as intestinal perforation and hemorrhage can be seen in early stage of GPA despite the rarity of intestinal involvement. In addition to high-dose steroids, anti-CD20 antibody Rituximab, was able to achieve successful induction and maintenance of remission." @default.
• W2979152034 created "2019-10-10" @default.
• W2979152034 creator A5021741152 @default.
• W2979152034 creator A5045058458 @default.
• W2979152034 creator A5054730894 @default.
• W2979152034 creator A5059478351 @default.
• W2979152034 creator A5069517938 @default.
• W2979152034 date "2015-10-01" @default.
• W2979152034 modified "2023-10-14" @default.
• W2979152034 title "In the Knick of Time: A Case of Bowel Perforation in Granulomatosis With Polyangiitis and the Use of Rituximab" @default.
• W2979152034 doi "https://doi.org/10.14309/00000434-201510001-00408" @default.
• W2979152034 hasPublicationYear "2015" @default.
• W2979152034 type Work @default.
• W2979152034 sameAs 2979152034 @default.
• W2979152034 citedByCount "0" @default.
• W2979152034 crossrefType "journal-article" @default.
• W2979152034 hasAuthorship W2979152034A5021741152 @default.
• W2979152034 hasAuthorship W2979152034A5045058458 @default.
• W2979152034 hasAuthorship W2979152034A5054730894 @default.
• W2979152034 hasAuthorship W2979152034A5059478351 @default.
• W2979152034 hasAuthorship W2979152034A5069517938 @default.
• W2979152034 hasConcept C126322002 @default.
• W2979152034 hasConcept C141071460 @default.
• W2979152034 hasConcept C191897082 @default.
• W2979152034 hasConcept C192562407 @default.
• W2979152034 hasConcept C2776015282 @default.
• W2979152034 hasConcept C2778456384 @default.
• W2979152034 hasConcept C2778527123 @default.
• W2979152034 hasConcept C2778720950 @default.
• W2979152034 hasConcept C2778910314 @default.
• W2979152034 hasConcept C2778966966 @default.
• W2979152034 hasConcept C2779134260 @default.
• W2979152034 hasConcept C2779338263 @default.
• W2979152034 hasConcept C2780199535 @default.
• W2979152034 hasConcept C2780356529 @default.
• W2979152034 hasConcept C2780653079 @default.
• W2979152034 hasConcept C2780955771 @default.
• W2979152034 hasConcept C2781229154 @default.
• W2979152034 hasConcept C71924100 @default.
• W2979152034 hasConceptScore W2979152034C126322002 @default.
• W2979152034 hasConceptScore W2979152034C141071460 @default.
• W2979152034 hasConceptScore W2979152034C191897082 @default.
• W2979152034 hasConceptScore W2979152034C192562407 @default.
• W2979152034 hasConceptScore W2979152034C2776015282 @default.
• W2979152034 hasConceptScore W2979152034C2778456384 @default.
• W2979152034 hasConceptScore W2979152034C2778527123 @default.
• W2979152034 hasConceptScore W2979152034C2778720950 @default.
• W2979152034 hasConceptScore W2979152034C2778910314 @default.
• W2979152034 hasConceptScore W2979152034C2778966966 @default.
• W2979152034 hasConceptScore W2979152034C2779134260 @default.
• W2979152034 hasConceptScore W2979152034C2779338263 @default.
• W2979152034 hasConceptScore W2979152034C2780199535 @default.
• W2979152034 hasConceptScore W2979152034C2780356529 @default.
• W2979152034 hasConceptScore W2979152034C2780653079 @default.
• W2979152034 hasConceptScore W2979152034C2780955771 @default.
• W2979152034 hasConceptScore W2979152034C2781229154 @default.
• W2979152034 hasConceptScore W2979152034C71924100 @default.
• W2979152034 hasLocation W29791520341 @default.
• W2979152034 hasOpenAccess W2979152034 @default.
• W2979152034 hasPrimaryLocation W29791520341 @default.
• W2979152034 hasRelatedWork W2080721448 @default.
• W2979152034 hasRelatedWork W2108422147 @default.
• W2979152034 hasRelatedWork W2137080874 @default.
• W2979152034 hasRelatedWork W2331407017 @default.
• W2979152034 hasRelatedWork W2471422969 @default.
• W2979152034 hasRelatedWork W2583153491 @default.
• W2979152034 hasRelatedWork W2993793844 @default.
• W2979152034 hasRelatedWork W3040579482 @default.
• W2979152034 hasRelatedWork W3158575776 @default.
• W2979152034 hasRelatedWork W3197765824 @default.
• W2979152034 hasVolume "110" @default.
• W2979152034 isParatext "false" @default.
• W2979152034 isRetracted "false" @default.
• W2979152034 magId "2979152034" @default.
• W2979152034 workType "article" @default.