Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979171250> ?p ?o ?g. }
- W2979171250 endingPage "1626" @default.
- W2979171250 startingPage "1626" @default.
- W2979171250 abstract "Numerous treatments have been developed to promote wound healing based on current understandings of the healing process. Hemorrhaging, clotting, and associated inflammation regulate early wound healing. We investigated treatment with a virus-derived immune modulating serine protease inhibitor (SERPIN), Serp-1, which inhibits thrombolytic proteases and inflammation, in a mouse excisional wound model. Saline or recombinant Serp-1 were applied directly to wounds as single doses of 1 μg or 2 µg or as two 1 µg boluses. A chitosan-collagen hydrogel was also tested for Serp-1 delivery. Wound size was measured daily for 15 days and scarring assessed by Masson’s trichrome, Herovici’s staining, and immune cell dynamics and angiogenesis by immunohistochemistry. Serp-1 treatment significantly accelerated wound healing, but was blocked by urokinase-type plasminogen activator (uPAR) antibody. Repeated dosing at a lower concentration was more effective than single high-dose serpin. A single application of Serp-1-loaded chitosan-collagen hydrogel was as effective as repeated aqueous Serp-1 dosing. Serp-1 treatment of wounds increased arginase-1-expressing M2-polarized macrophage counts and periwound angiogenesis in the wound bed. Collagen staining also demonstrated that Serp-1 improves collagen maturation and organization at the wound site. Serp-1 has potential as a safe and effective immune modulating treatment that targets thrombolytic proteases, accelerating healing and reducing scar in deep cutaneous wounds." @default.
- W2979171250 created "2019-10-10" @default.
- W2979171250 creator A5039522169 @default.
- W2979171250 creator A5040591138 @default.
- W2979171250 creator A5040683452 @default.
- W2979171250 creator A5053755267 @default.
- W2979171250 creator A5074382441 @default.
- W2979171250 creator A5087278493 @default.
- W2979171250 creator A5088091907 @default.
- W2979171250 creator A5089171585 @default.
- W2979171250 creator A5091823760 @default.
- W2979171250 date "2019-10-04" @default.
- W2979171250 modified "2023-10-03" @default.
- W2979171250 title "A Virus-Derived Immune Modulating Serpin Accelerates Wound Closure with Improved Collagen Remodeling" @default.
- W2979171250 cites W1518095394 @default.
- W2979171250 cites W1597336200 @default.
- W2979171250 cites W1797422316 @default.
- W2979171250 cites W1949832432 @default.
- W2979171250 cites W1964983194 @default.
- W2979171250 cites W1969516145 @default.
- W2979171250 cites W1977631233 @default.
- W2979171250 cites W1986410103 @default.
- W2979171250 cites W1989727926 @default.
- W2979171250 cites W2002385252 @default.
- W2979171250 cites W2016450706 @default.
- W2979171250 cites W2019319143 @default.
- W2979171250 cites W2025763370 @default.
- W2979171250 cites W2029154524 @default.
- W2979171250 cites W2029497643 @default.
- W2979171250 cites W2030160629 @default.
- W2979171250 cites W2031856001 @default.
- W2979171250 cites W2037221633 @default.
- W2979171250 cites W2041404288 @default.
- W2979171250 cites W2041428471 @default.
- W2979171250 cites W2041591721 @default.
- W2979171250 cites W2043082612 @default.
- W2979171250 cites W2043771940 @default.
- W2979171250 cites W204511859 @default.
- W2979171250 cites W2045982747 @default.
- W2979171250 cites W2056064788 @default.
- W2979171250 cites W2057495467 @default.
- W2979171250 cites W2057724376 @default.
- W2979171250 cites W2075202324 @default.
- W2979171250 cites W2078059979 @default.
- W2979171250 cites W2078875140 @default.
- W2979171250 cites W2085893043 @default.
- W2979171250 cites W2087759495 @default.
- W2979171250 cites W2099938825 @default.
- W2979171250 cites W2102565647 @default.
- W2979171250 cites W2105450155 @default.
- W2979171250 cites W2109064884 @default.
- W2979171250 cites W2118654016 @default.
- W2979171250 cites W2124719493 @default.
- W2979171250 cites W2125833857 @default.
- W2979171250 cites W2127903487 @default.
- W2979171250 cites W2128734424 @default.
- W2979171250 cites W2132266700 @default.
- W2979171250 cites W2132535512 @default.
- W2979171250 cites W2140380746 @default.
- W2979171250 cites W2142142797 @default.
- W2979171250 cites W2146575741 @default.
- W2979171250 cites W2146693164 @default.
- W2979171250 cites W2148356659 @default.
- W2979171250 cites W2153805013 @default.
- W2979171250 cites W2159560463 @default.
- W2979171250 cites W2163105501 @default.
- W2979171250 cites W2164434058 @default.
- W2979171250 cites W2166760112 @default.
- W2979171250 cites W2167279371 @default.
- W2979171250 cites W2301044272 @default.
- W2979171250 cites W2320716983 @default.
- W2979171250 cites W2325727928 @default.
- W2979171250 cites W2342473733 @default.
- W2979171250 cites W2353982544 @default.
- W2979171250 cites W2395452187 @default.
- W2979171250 cites W2396261945 @default.
- W2979171250 cites W2415894811 @default.
- W2979171250 cites W2418612772 @default.
- W2979171250 cites W2473048437 @default.
- W2979171250 cites W2476542314 @default.
- W2979171250 cites W2521459783 @default.
- W2979171250 cites W2567221680 @default.
- W2979171250 cites W2580555388 @default.
- W2979171250 cites W2590194110 @default.
- W2979171250 cites W2596984373 @default.
- W2979171250 cites W2609179980 @default.
- W2979171250 cites W2636808498 @default.
- W2979171250 cites W2734365706 @default.
- W2979171250 cites W2755970326 @default.
- W2979171250 cites W2774078753 @default.
- W2979171250 cites W2786873277 @default.
- W2979171250 cites W2790462592 @default.
- W2979171250 cites W2791633954 @default.
- W2979171250 cites W2807020794 @default.
- W2979171250 cites W2892397780 @default.
- W2979171250 cites W2898412730 @default.
- W2979171250 cites W2898701316 @default.
- W2979171250 doi "https://doi.org/10.3390/jcm8101626" @default.