FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979185870> ?p ?o ?g. }

• W2979185870 endingPage "1738" @default.
• W2979185870 startingPage "1728" @default.
• W2979185870 abstract "Fundamental mechanisms governing cell size control and homeostasis are still poorly understood. The relationship between sizes at division and birth in single cells is used as a metric to categorize the basis of size homeostasis [1-3]. Cells dividing at a fixed size regardless of birth size (sizer) are expected to show a division-birth slope of 0, whereas cells dividing after growing for a fixed size increment (adder) have an expected slope of +1 [4]. These two theoretical values are, however, rarely experimentally observed. For example, rod-shaped fission yeast $it{Schizosaccharomyces}$ $it{pombe}$ cells, which divide at a fixed surface area [5, 6], exhibit a division-birth slope for cell lengths of 0.25$pm$0.02, significantly different from the expected sizer value of zero. Here we investigate possible reasons for this discrepancy by developing a mathematical model of sizer control including the relevant sources of variation. Our results support $it{pure}$ sizer control and show that deviation from zero slope is exaggerated by measurement of an inappropriate geometrical quantity (e.g., length instead of area), combined with cell-to-cell radius variability. The model predicts that mutants with greater errors in size sensing or septum positioning paradoxically appear to behave as better sizers. Furthermore, accounting for cell width variability, we show that pure sizer control can in some circumstances reproduce the apparent adder behaviour observed in $it{E. coli}$. These findings demonstrate that analysis of geometric variation can lead to new insights into cell size control." @default.
• W2979185870 created "2019-10-10" @default.
• W2979185870 creator A5004103488 @default.
• W2979185870 creator A5053576815 @default.
• W2979185870 creator A5066096419 @default.
• W2979185870 creator A5082789932 @default.
• W2979185870 date "2019-11-01" @default.
• W2979185870 modified "2023-09-30" @default.
• W2979185870 title "Reassessment of the Basis of Cell Size Control Based on Analysis of Cell-to-Cell Variability" @default.
• W2979185870 cites W1780666943 @default.
• W2979185870 cites W1829149466 @default.
• W2979185870 cites W1883779479 @default.
• W2979185870 cites W1966062610 @default.
• W2979185870 cites W1976899385 @default.
• W2979185870 cites W2028457150 @default.
• W2979185870 cites W2044341058 @default.
• W2979185870 cites W2049746824 @default.
• W2979185870 cites W2056967573 @default.
• W2979185870 cites W2066320596 @default.
• W2979185870 cites W2098145231 @default.
• W2979185870 cites W2123999282 @default.
• W2979185870 cites W2155821939 @default.
• W2979185870 cites W2158232463 @default.
• W2979185870 cites W2167279371 @default.
• W2979185870 cites W2167347687 @default.
• W2979185870 cites W2273741954 @default.
• W2979185870 cites W2485910554 @default.
• W2979185870 cites W2548342201 @default.
• W2979185870 cites W2562979668 @default.
• W2979185870 cites W2589396559 @default.
• W2979185870 cites W2590998239 @default.
• W2979185870 cites W2605452982 @default.
• W2979185870 cites W2736339683 @default.
• W2979185870 cites W2750653488 @default.
• W2979185870 cites W2751416180 @default.
• W2979185870 cites W2759835433 @default.
• W2979185870 cites W2766164287 @default.
• W2979185870 cites W2773575749 @default.
• W2979185870 cites W2910129136 @default.
• W2979185870 cites W2931448452 @default.
• W2979185870 cites W2951525168 @default.
• W2979185870 doi "https://doi.org/10.1016/j.bpj.2019.09.031" @default.
• W2979185870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6838950" @default.
• W2979185870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31630810" @default.
• W2979185870 hasPublicationYear "2019" @default.
• W2979185870 type Work @default.
• W2979185870 sameAs 2979185870 @default.
• W2979185870 citedByCount "19" @default.
• W2979185870 countsByYear W29791858702020 @default.
• W2979185870 countsByYear W29791858702021 @default.
• W2979185870 countsByYear W29791858702022 @default.
• W2979185870 countsByYear W29791858702023 @default.
• W2979185870 crossrefType "journal-article" @default.
• W2979185870 hasAuthorship W2979185870A5004103488 @default.
• W2979185870 hasAuthorship W2979185870A5053576815 @default.
• W2979185870 hasAuthorship W2979185870A5066096419 @default.
• W2979185870 hasAuthorship W2979185870A5082789932 @default.
• W2979185870 hasBestOaLocation W29791858701 @default.
• W2979185870 hasConcept C121332964 @default.
• W2979185870 hasConcept C12294094 @default.
• W2979185870 hasConcept C1491633281 @default.
• W2979185870 hasConcept C152568617 @default.
• W2979185870 hasConcept C178635117 @default.
• W2979185870 hasConcept C3017597547 @default.
• W2979185870 hasConcept C33923547 @default.
• W2979185870 hasConcept C38652104 @default.
• W2979185870 hasConcept C41008148 @default.
• W2979185870 hasConcept C54355233 @default.
• W2979185870 hasConcept C62520636 @default.
• W2979185870 hasConcept C85813293 @default.
• W2979185870 hasConcept C86803240 @default.
• W2979185870 hasConcept C95444343 @default.
• W2979185870 hasConceptScore W2979185870C121332964 @default.
• W2979185870 hasConceptScore W2979185870C12294094 @default.
• W2979185870 hasConceptScore W2979185870C1491633281 @default.
• W2979185870 hasConceptScore W2979185870C152568617 @default.
• W2979185870 hasConceptScore W2979185870C178635117 @default.
• W2979185870 hasConceptScore W2979185870C3017597547 @default.
• W2979185870 hasConceptScore W2979185870C33923547 @default.
• W2979185870 hasConceptScore W2979185870C38652104 @default.
• W2979185870 hasConceptScore W2979185870C41008148 @default.
• W2979185870 hasConceptScore W2979185870C54355233 @default.
• W2979185870 hasConceptScore W2979185870C62520636 @default.
• W2979185870 hasConceptScore W2979185870C85813293 @default.
• W2979185870 hasConceptScore W2979185870C86803240 @default.
• W2979185870 hasConceptScore W2979185870C95444343 @default.
• W2979185870 hasIssue "9" @default.
• W2979185870 hasLocation W29791858701 @default.
• W2979185870 hasLocation W29791858702 @default.
• W2979185870 hasLocation W29791858703 @default.
• W2979185870 hasLocation W29791858704 @default.
• W2979185870 hasLocation W29791858705 @default.
• W2979185870 hasLocation W29791858706 @default.
• W2979185870 hasOpenAccess W2979185870 @default.
• W2979185870 hasPrimaryLocation W29791858701 @default.
• W2979185870 hasRelatedWork W2007036770 @default.
• W2979185870 hasRelatedWork W2058643295 @default.
• W2979185870 hasRelatedWork W2059729638 @default.

• next