FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979206168> ?p ?o ?g. }

• W2979206168 endingPage "S634" @default.
• W2979206168 startingPage "S634" @default.
• W2979206168 abstract "Purpose: The clinical implications of the profound biological differences in CRC between women and men are largely underappreciated. Our group has noted a “gender paradox” for advanced adenomas and CRC in women and men which may have potential ramifications for screening (JAMA 2009;302:1696-7). We have noted that changes in field carcinogenesis (reviewed in Gastroenterology 2011;140:35-41) may also be gender specific (Cancer Prev Res 2010;3:844-51). With regards to risk factor, the role of obesity is becoming increasingly dominant. Emerging data indicates that men appear to be disproportionately impacted versus women (reviewed by Bardou, et al. Gut 2013;62:933-47). Understanding which obese patients are at elevated risk of CRC is critical. We, therefore, evaluated fatty acid synthase (FASN), a protein implicated in the “lipogenic switch” in early colon carcinogenesis. FASN has been implicated in frank CRCs but little is known about the role of FASN in early events such as field carcinogenesis or its gender predilection. Methods: Two biopsies were obtained from endoscopically normal rectum from 103 patients undergoing screening colonoscopy. Subjects were dichotomized into non-obese and obese using a BMI of 30 as a cut point. Biopsies were subjected to real time PCR analysis for FASN and normalized with beta-actin. Results: Obese patients had an induction of FASN when compared to corresponding non-obese subjects (controls 50%, adenoma-harboring 29%, p<0.05). Rectal FASN was highly overexpressed in adenoma patients versus controls and this was a much more dramatic effect in men than women (see Figure). ANCOVA analysis suggested no significant confounding with age, adenoma size, smoking status, etc.FigureConclusion: We report herein, for the first time, alterations in FASN in patients harboring adenomas. This was accentuated in obese patients suggesting a potential molecular link between obesity and colonic neoplasia. Importantly, the effect was more marked in males than females, consonant with the obesity-CRC epidemiology. These insights into the molecular pathogenesis of obesity-related CRC suggest a role of this “lipogenic switch” in gender differences in CRC. Furthermore, this may be a “druggable” target against obesity-induced CRC and also provide a biomarker for determining at risk patients, thus enabling personalizing CRC prevention strategies." @default.
• W2979206168 created "2019-10-10" @default.
• W2979206168 creator A5023616353 @default.
• W2979206168 creator A5030946583 @default.
• W2979206168 creator A5037709673 @default.
• W2979206168 creator A5062415571 @default.
• W2979206168 creator A5079107177 @default.
• W2979206168 creator A5079825958 @default.
• W2979206168 date "2013-10-01" @default.
• W2979206168 modified "2023-10-16" @default.
• W2979206168 title "Fatty Acid Synthase in the Endoscopically Normal Rectal Mucosa as Marker for Obesity-related Colorectal Cancer (CRC) Risk: Gender-specific Implications: Presidential Poster" @default.
• W2979206168 doi "https://doi.org/10.14309/00000434-201310001-02087" @default.
• W2979206168 hasPublicationYear "2013" @default.
• W2979206168 type Work @default.
• W2979206168 sameAs 2979206168 @default.
• W2979206168 citedByCount "0" @default.
• W2979206168 crossrefType "journal-article" @default.
• W2979206168 hasAuthorship W2979206168A5023616353 @default.
• W2979206168 hasAuthorship W2979206168A5030946583 @default.
• W2979206168 hasAuthorship W2979206168A5037709673 @default.
• W2979206168 hasAuthorship W2979206168A5062415571 @default.
• W2979206168 hasAuthorship W2979206168A5079107177 @default.
• W2979206168 hasAuthorship W2979206168A5079825958 @default.
• W2979206168 hasConcept C121608353 @default.
• W2979206168 hasConcept C126322002 @default.
• W2979206168 hasConcept C134018914 @default.
• W2979206168 hasConcept C143998085 @default.
• W2979206168 hasConcept C2776861080 @default.
• W2979206168 hasConcept C2777428134 @default.
• W2979206168 hasConcept C2777936439 @default.
• W2979206168 hasConcept C2778435480 @default.
• W2979206168 hasConcept C2780586474 @default.
• W2979206168 hasConcept C2781074409 @default.
• W2979206168 hasConcept C4733338 @default.
• W2979206168 hasConcept C48289651 @default.
• W2979206168 hasConcept C511355011 @default.
• W2979206168 hasConcept C526805850 @default.
• W2979206168 hasConcept C555283112 @default.
• W2979206168 hasConcept C71924100 @default.
• W2979206168 hasConcept C90924648 @default.
• W2979206168 hasConceptScore W2979206168C121608353 @default.
• W2979206168 hasConceptScore W2979206168C126322002 @default.
• W2979206168 hasConceptScore W2979206168C134018914 @default.
• W2979206168 hasConceptScore W2979206168C143998085 @default.
• W2979206168 hasConceptScore W2979206168C2776861080 @default.
• W2979206168 hasConceptScore W2979206168C2777428134 @default.
• W2979206168 hasConceptScore W2979206168C2777936439 @default.
• W2979206168 hasConceptScore W2979206168C2778435480 @default.
• W2979206168 hasConceptScore W2979206168C2780586474 @default.
• W2979206168 hasConceptScore W2979206168C2781074409 @default.
• W2979206168 hasConceptScore W2979206168C4733338 @default.
• W2979206168 hasConceptScore W2979206168C48289651 @default.
• W2979206168 hasConceptScore W2979206168C511355011 @default.
• W2979206168 hasConceptScore W2979206168C526805850 @default.
• W2979206168 hasConceptScore W2979206168C555283112 @default.
• W2979206168 hasConceptScore W2979206168C71924100 @default.
• W2979206168 hasConceptScore W2979206168C90924648 @default.
• W2979206168 hasLocation W29792061681 @default.
• W2979206168 hasOpenAccess W2979206168 @default.
• W2979206168 hasPrimaryLocation W29792061681 @default.
• W2979206168 hasRelatedWork W1480877157 @default.
• W2979206168 hasRelatedWork W1996195452 @default.
• W2979206168 hasRelatedWork W2084509227 @default.
• W2979206168 hasRelatedWork W2087469500 @default.
• W2979206168 hasRelatedWork W2328977712 @default.
• W2979206168 hasRelatedWork W2376842472 @default.
• W2979206168 hasRelatedWork W2429373311 @default.
• W2979206168 hasRelatedWork W2896077670 @default.
• W2979206168 hasRelatedWork W4214586591 @default.
• W2979206168 hasRelatedWork W4282010316 @default.
• W2979206168 hasVolume "108" @default.
• W2979206168 isParatext "false" @default.
• W2979206168 isRetracted "false" @default.
• W2979206168 magId "2979206168" @default.
• W2979206168 workType "article" @default.